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eIF3S6IP
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2. Belongs to the eIF-3 subunit L family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding; Translation; Translation initiation |
| Chromosomal Location of human Ortholog: 22q13.1 |
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Cellular Component:
cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; fibrillar center; nucleoplasm; synapse
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Molecular Function:
protein binding; translation initiation factor activity
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Biological Process:
formation of cytoplasmic translation initiation complex; translational initiation; viral translational termination-reinitiation
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Reference #:
Q9Y262
(UniProtKB)
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Alt. Names/Synonyms: eIEF associated protein HSPC021; EIF3EIP; EIF3L; EIF3S11; EIF3S6IP; Eukaryotic translation initiation factor 3 subunit 6-interacting protein; Eukaryotic translation initiation factor 3 subunit E-interacting protein; Eukaryotic translation initiation factor 3 subunit L; eukaryotic translation initiation factor 3, subunit 6 interacting protein; eukaryotic translation initiation factor 3, subunit E interacting protein; eukaryotic translation initiation factor 3, subunit L; HSPC021; HSPC025; MSTP005
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Gene Symbols: EIF3L
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Molecular weight:
66,727 Da
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Basal Isoelectric point:
5.93
Predict pI for various phosphorylation states
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