|
CD3G
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G. Note: This description may include information from UniProtKB.
|
| Protein type: Membrane protein, integral; Receptor, misc. |
| Chromosomal Location of Human Ortholog: 9 A5.2|9 24.84 cM |
|
Cellular Component:
alpha-beta T cell receptor complex; external side of plasma membrane; integral component of membrane; membrane
|
|
Molecular Function:
protein binding; protein heterodimerization activity; protein homodimerization activity; transmembrane signaling receptor activity
|
|
Biological Process:
adaptive immune response; cell surface receptor signaling pathway; establishment or maintenance of cell polarity; immune system process; positive thymic T cell selection; protein homooligomerization; protein transport; regulation of lymphocyte apoptotic process; T cell differentiation
|
|
Reference #:
P11942
(UniProtKB)
|
|
Alt. Names/Synonyms: CD3 antigen, gamma polypeptide; Cd3g; Ctg-3; Ctg3; T-cell receptor T3 gamma chain; T-cell surface glycoprotein CD3 gamma chain; T3g
|
|
Gene Symbols: Cd3g
|
|
Molecular weight:
20,234 Da
|
|
Basal Isoelectric point:
9.03
Predict pI for various phosphorylation states
|
|
CST Pathways:
T Cell Receptor Signaling
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
