H1C Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Cellular Component:  nucleosome; transcriptionally active chromatin
Molecular Function:  protein binding
Biological Process:  histone H3-K27 trimethylation; histone H3-K4 trimethylation; negative regulation of transcription by RNA polymerase II; nucleosome assembly
Reference #:  P02253 (UniProtKB)
Alt. Names/Synonyms: H1-2; H1.2 linker histone, cluster member; H11; H12; H1C; histone cluster 1, H1c; histone H1.1; Histone H1.2
Gene Symbols: H1-2
Molecular weight: 21,356 Da
Basal Isoelectric point: 11.01  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene