5-HT(3) This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
Chromosomal Location of mouse Ortholog: 9|9 A5.3
Cellular Component:  axon; cleavage furrow; glutamatergic synapse; membrane; neuron projection; neuronal cell body; plasma membrane; postsynaptic membrane; presynaptic membrane; serotonin-activated cation-selective channel complex; synapse
Molecular Function:  acetylcholine-gated monoatomic cation-selective channel activity; extracellular ligand-gated monoatomic ion channel activity; identical protein binding; ligand-gated monoatomic ion channel activity; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; monoatomic ion channel activity; serotonin binding; serotonin-gated monoatomic cation-selective channel activity; transmembrane signaling receptor activity
Biological Process:  chemical synaptic transmission; inorganic cation transmembrane transport; monoatomic ion transmembrane transport; monoatomic ion transport; nervous system process; positive regulation of ion transmembrane transporter activity; regulation of membrane potential; regulation of presynaptic membrane potential; serotonin receptor signaling pathway; signal transduction
Reference #:  P23979 (UniProtKB)
Alt. Names/Synonyms: 5-HT(3); 5-HT-3; 5-HT3; 5-HT3 receptor; 5-HT3-A; 5-HT3A; 5-HT3R; 5-hydroxytryptamine (serotonin) receptor 3A; 5-hydroxytryptamine receptor 3; 5-hydroxytryptamine receptor 3A; 5ht3; 5HT3 serotonin receptor; 5HT3A; Htr3; Htr3a; Serotonin receptor 3A; Serotonin-gated ion channel receptor
Gene Symbols: Htr3a
Molecular weight: 56,225 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
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5-HT(3)

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein