GluR6 Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 subfamily. Expression is higher in cerebellum than in cerebral cortex. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 6q16.3
Cellular Component:  cell junction; dendrite cytoplasm; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; integral component of plasma membrane; perikaryon; plasma membrane; postsynaptic density; terminal bouton
Molecular Function:  extracellularly glutamate-gated ion channel activity; kainate selective glutamate receptor activity; ligand-gated ion channel activity involved in regulation of presynaptic membrane potential; PDZ domain binding; protein homodimerization activity; ubiquitin conjugating enzyme binding; ubiquitin protein ligase binding
Biological Process:  behavioral fear response; cellular calcium ion homeostasis; chemical synaptic transmission; excitatory postsynaptic potential; glutamate receptor signaling pathway; inhibitory postsynaptic potential; ion transmembrane transport; ionotropic glutamate receptor signaling pathway; modulation of chemical synaptic transmission; negative regulation of neuron apoptotic process; negative regulation of synaptic transmission, glutamatergic; neuron apoptotic process; neuronal action potential; positive regulation of neuron apoptotic process; positive regulation of synaptic transmission; receptor clustering; regulation of JNK cascade; regulation of long-term neuronal synaptic plasticity; regulation of presynaptic membrane potential; regulation of short-term neuronal synaptic plasticity
Disease: Mental Retardation, Autosomal Recessive 6; Neurodevelopmental Disorder With Impaired Language And Ataxia And With Or Without Seizures
Reference #:  Q13002 (UniProtKB)
Alt. Names/Synonyms: bA487F5.1; EAA4; Excitatory amino acid receptor 4; GLR6; GluK2; GLUK6; GluR-6; GLUR6; glutamate ionotropic receptor kainate type subunit 2; Glutamate receptor 6; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; Glutamate receptor ionotropic, kainate 2; Glutamate receptor, ionotropic kainate 2; glutamate receptor, ionotropic, kainate 2; GRIK2; MGC74427; MRT6
Gene Symbols: GRIK2
Molecular weight: 102,583 Da
Basal Isoelectric point: 8.05  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein