helicase B 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection. Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB. As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation. Acts independently of TP53BP1. Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress. Belongs to the RecD family. HELB subfamily. Highly expressed in testis and thymus and weakly in liver, spleen, kidney and brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA replication; EC; Helicase
Chromosomal Location of Human Ortholog: 10 D2|10 67.94 cM
Cellular Component:  chromosome; cytoplasm; nucleus; site of double-strand break
Molecular Function:  ATP binding; ATP-dependent 5'-3' DNA helicase activity; ATP-dependent DNA helicase activity; helicase activity; hydrolase activity; nucleotide binding; protein-containing complex binding; RNA binding; single-stranded DNA-dependent ATP-dependent DNA helicase activity
Biological Process:  cellular response to DNA damage stimulus; DNA replication; DNA replication, synthesis of RNA primer; DNA-dependent DNA replication; negative regulation of double-strand break repair via homologous recombination; regulation of DNA double-strand break processing
Reference #:  Q6NVF4 (UniProtKB)
Alt. Names/Synonyms: AI447783; D10Ertd664; D10Ertd664e; DNA helicase B; Helb; helicase (DNA) B; helicase B
Gene Symbols: Helb
Molecular weight: 121,471 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
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helicase B

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene