FGF2 Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue. 4 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Activator; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3 B|3 18.41 cM
Cellular Component:  cytoplasm; extracellular region; extracellular space; nucleus
Molecular Function:  chemoattractant activity; cytokine activity; fibroblast growth factor receptor binding; growth factor activity; heparin binding; integrin binding; nuclear receptor transcription coactivator activity; protein binding; receptor-receptor interaction
Biological Process:  activation of MAPKK activity; angiogenesis; angiogenesis involved in coronary vascular morphogenesis; branching involved in ureteric bud morphogenesis; cardiac muscle cell proliferation; cell differentiation; cell migration involved in sprouting angiogenesis; chondroblast differentiation; corticotropin hormone secreting cell differentiation; embryo development ending in birth or egg hatching; fibroblast growth factor receptor signaling pathway; glial cell differentiation; growth factor dependent regulation of skeletal muscle satellite cell proliferation; hyaluronan catabolic process; inositol phosphate biosynthetic process; lung development; mammary gland epithelial cell differentiation; multicellular organism development; negative regulation of blood vessel endothelial cell migration; negative regulation of cell death; negative regulation of cell proliferation; negative regulation of fibroblast migration; negative regulation of wound healing; organ induction; paracrine signaling; phosphatidylinositol biosynthetic process; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of canonical Wnt signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of cell differentiation; positive regulation of cell division; positive regulation of cell fate specification; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell proliferation; positive regulation of cerebellar granule cell precursor proliferation; positive regulation of DNA biosynthetic process; positive regulation of endothelial cell chemotaxis; positive regulation of endothelial cell chemotaxis to fibroblast growth factor; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of MAP kinase activity; positive regulation of osteoblast differentiation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phospholipase C activity; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of sprouting angiogenesis; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of vascular endothelial cell proliferation; positive regulation of vascular smooth muscle cell proliferation; regulation of cell cycle; regulation of endothelial cell chemotaxis to fibroblast growth factor; regulation of retinal cell programmed cell death; release of sequestered calcium ion into cytosol; response to axon injury; stem cell development; substantia nigra development; thyroid-stimulating hormone-secreting cell differentiation; wound healing
Reference #:  P15655 (UniProtKB)
Alt. Names/Synonyms: Basic fibroblast growth factor; BFGF; Fgf-2; Fgf2; Fgfb; Fibroblast growth factor 2; HBGF-2; Heparin-binding growth factor 2
Gene Symbols: Fgf2
Molecular weight: 17,153 Da
Basal Isoelectric point: 9.58  Predict pI for various phosphorylation states
Select Structure to View Below

FGF2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene