5-HT(3) This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
Chromosomal Location of Human Ortholog: 11q23.2
Cellular Component:  axon; cell junction; cleavage furrow; cytoplasm; glutamatergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane; neuronal cell body; plasma membrane; serotonin-activated cation-selective channel complex
Molecular Function:  protein binding; serotonin binding; serotonin-gated cation-selective channel activity; transmembrane signaling receptor activity
Biological Process:  cellular response to growth factor stimulus; chemical synaptic transmission; positive regulation of ion transmembrane transporter activity; response to cocaine; response to ethanol; serotonin receptor signaling pathway
Reference #:  P46098 (UniProtKB)
Alt. Names/Synonyms: 5-HT-3; 5-HT3-A; 5-HT3A; 5-HT3R; 5-hydroxytryptamine (serotonin) receptor 3A; 5-hydroxytryptamine receptor 3; 5-hydroxytryptamine receptor 3A; 5HT3 serotonin receptor; 5HT3A; 5HT3R; HTR3; HTR3A; Serotonin receptor 3A; Serotonin-gated ion channel receptor
Gene Symbols: HTR3A
Molecular weight: 55,280 Da
Basal Isoelectric point: 7.04  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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