5-HT(3) This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel

Chromosomal Location of human Ortholog: 11q23.2

Cellular Component: cleavage furrow; neuron projection; plasma membrane; postsynaptic membrane; serotonin-activated cation-selective channel complex; synapse

Molecular Function: acetylcholine-gated monoatomic cation-selective channel activity; protein binding; serotonin binding; serotonin-gated monoatomic cation-selective channel activity

Biological Process: chemical synaptic transmission; excitatory postsynaptic potential; inorganic cation transmembrane transport; monoatomic ion transmembrane transport; nervous system process; regulation of membrane potential; serotonin receptor signaling pathway; signal transduction

Reference #: P46098 (UniProtKB)

Alt. Names/Synonyms: 5-HT(3); 5-HT-3; 5-HT3-A; 5-HT3A; 5-HT3R; 5-hydroxytryptamine (serotonin) receptor 3A; 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic; 5-hydroxytryptamine receptor 3; 5-hydroxytryptamine receptor 3A; 5HT3 serotonin receptor; 5HT3A; 5HT3R; HTR3; HTR3A; Serotonin receptor 3A; Serotonin-gated ion channel receptor

Gene Symbols: HTR3A

Molecular weight: 55,280 Da

Basal Isoelectric point: 7.04 Predict pI for various phosphorylation states

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5-HT(3)

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