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ADRA2A
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of Human Ortholog: 10q25.2 |
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Cellular Component:
basolateral plasma membrane; cytoplasm; integral component of plasma membrane; plasma membrane; receptor complex
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Molecular Function:
alpha-1B adrenergic receptor binding; alpha-2C adrenergic receptor binding; alpha2-adrenergic receptor activity; epinephrine binding; heterotrimeric G-protein binding; norepinephrine binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; thioesterase binding
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Biological Process:
actin cytoskeleton organization; activation of protein kinase activity; activation of protein kinase B activity; adenylate cyclase-activating adrenergic receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting adrenergic receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adrenergic receptor signaling pathway; cellular response to hormone stimulus; G protein-coupled receptor signaling pathway; glucose homeostasis; intestinal absorption; negative regulation of calcium ion transmembrane transporter activity; negative regulation of calcium ion transport; negative regulation of calcium ion-dependent exocytosis; negative regulation of epinephrine secretion; negative regulation of insulin secretion; negative regulation of insulin secretion involved in cellular response to glucose stimulus; negative regulation of lipid catabolic process; negative regulation of norepinephrine secretion; phospholipase C-activating adrenergic receptor signaling pathway; platelet activation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cytokine production; positive regulation of epidermal growth factor-activated receptor activity; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of membrane protein ectodomain proteolysis; positive regulation of potassium ion transport; positive regulation of wound healing; Ras protein signal transduction; receptor transactivation; regulation of insulin secretion; regulation of smooth muscle contraction; regulation of vasoconstriction; Rho protein signal transduction
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Reference #:
P08913
(UniProtKB)
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Alt. Names/Synonyms: ADA2A; ADRA2; ADRA2A; ADRA2R; ADRAR; adrenergic, alpha-2A-, receptor; adrenoceptor alpha 2A; Alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type; Alpha-2A adrenergic receptor; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; Alpha-2AAR; alpha-2AAR subtype C10; ALPHA2AAR; ZNF32
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Gene Symbols: ADRA2A
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Molecular weight:
50,647 Da
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Basal Isoelectric point:
9.75
Predict pI for various phosphorylation states
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