kindlin-3 Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. Belongs to the kindlin family. Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component:  cell junction; cell projection; extracellular region; platelet alpha granule lumen; podosome
Molecular Function:  integrin binding
Biological Process:  integrin activation; integrin-mediated signaling pathway; leukocyte cell-cell adhesion; platelet aggregation; platelet degranulation; positive regulation of cell migration; regulation of cell-cell adhesion mediated by integrin; substrate adhesion-dependent cell spreading
Disease: Leukocyte Adhesion Deficiency, Type Iii
Reference #:  Q86UX7 (UniProtKB)
Alt. Names/Synonyms: Fermitin family homolog 3; fermitin family homolog 3 (Drosophila); FERMT3; KIND3; kindlin 3; Kindlin-3; MGC10966; MIG-2; MIG2-like protein; MIG2B; UNC-112 related protein 2; Unc-112-related protein 2; UNC112C; URP2; URP2SF
Gene Symbols: FERMT3
Molecular weight: 75,953 Da
Basal Isoelectric point: 6.53  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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kindlin-3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein