|
ITGA3 iso1
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Belongs to the integrin alpha chain family. Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. |
| Chromosomal Location of human Ortholog: 17q21.33 |
|
Cellular Component:
basolateral plasma membrane; cell periphery; cell surface; excitatory synapse; external side of plasma membrane; filopodium membrane; glutamatergic synapse; growth cone filopodium; integrin alpha3-beta1 complex; integrin complex; neuromuscular junction; perinuclear region of cytoplasm; plasma membrane; postsynaptic membrane; presynaptic active zone membrane; receptor complex; synaptic membrane
|
|
Molecular Function:
collagen binding; fibronectin binding; integrin binding; laminin binding; metal ion binding; protease binding; protein binding; protein domain specific binding; protein heterodimerization activity
|
|
Biological Process:
cell adhesion mediated by integrin; cell-cell adhesion; cell-matrix adhesion; dendritic spine maintenance; exploration behavior; heart development; integrin-mediated signaling pathway; leukocyte migration; lung development; maternal process involved in female pregnancy; memory; mesodermal cell differentiation; negative regulation of cell projection organization; negative regulation of Rho protein signal transduction; nephron development; neuron migration; positive regulation of cell-substrate adhesion; positive regulation of epithelial cell migration; positive regulation of gene expression; positive regulation of neuron projection development; positive regulation of protein localization to plasma membrane; regulation of BMP signaling pathway; regulation of transforming growth factor beta receptor signaling pathway; regulation of Wnt signaling pathway; renal filtration; response to gonadotropin; response to xenobiotic stimulus; Rho protein signal transduction; skin development; synaptic membrane adhesion
|
|
Reference #:
P26006-1
(UniProtKB)
|
|
Alt. Names/Synonyms: alpha 3 subunit of VLA-3 receptor; antigen CD49C; antigen identified by monoclonal antibody J143; CD49 antigen-like family member C; CD49C; FLJ34631; FLJ34704; FRP-2; Galactoprotein B3; GAP-B3; GAPB3; ILNEB; integrin alpha 3; Integrin alpha-3; Integrin alpha-3 heavy chain; Integrin alpha-3 light chain; integrin subunit alpha 3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); ITA3; ITGA3; ITGA3 iso1; MSK18; testicular tissue protein Li 96; testicular tissue protein Li 98; VCA-2; very late activation protein 3 receptor, alpha-3 subunit; VL3A; VLA-3 subunit alpha; VLA3a
|
|
Gene Symbols: ITGA3
|
|
Molecular weight:
118,756 Da
|
|
Basal Isoelectric point:
6.51
Predict pI for various phosphorylation states
|
|
CST Pathways:
Actin Dynamics
|
GPCR Signaling to MAPKs
|
Growth And Differentiation Control by MAPKs
|
PI3K/Akt Signaling
|
