DLG1 Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. Belongs to the MAGUK family. Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Widely expressed, with isoforms displaying different expression profiles. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16 B2|16 22.4 cM
Cellular Component:  basal plasma membrane; basement membrane; basolateral plasma membrane; bicellular tight junction; cell junction; cell projection membrane; cell-cell adherens junction; cell-cell junction; cytoplasm; cytoplasmic side of plasma membrane; cytosol; dendrite; endoplasmic reticulum; glutamatergic synapse; Golgi apparatus; immunological synapse; lateral loop; lateral plasma membrane; membrane; membrane raft; microtubule; microvillus; MPP7-DLG1-LIN7 complex; myelin sheath abaxonal region; neuromuscular junction; neuron projection; node of Ranvier; nucleus; paranode region of axon; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; postsynaptic density membrane; postsynaptic density, intracellular component; postsynaptic membrane; presynaptic membrane; synapse; T-tubule
Molecular Function:  ion channel binding; ionotropic glutamate receptor binding; kinase binding; kinesin binding; L27 domain binding; mitogen-activated protein kinase kinase binding; molecular adaptor activity; PDZ domain binding; phosphatase binding; potassium channel regulator activity; protein binding; protein C-terminus binding; protein kinase binding; structural constituent of postsynaptic density
Biological Process:  actin filament organization; activation of protein kinase activity; amyloid precursor protein metabolic process; astral microtubule organization; bicellular tight junction assembly; branching involved in ureteric bud morphogenesis; cell-cell adhesion; cellular protein-containing complex localization; chemical synaptic transmission; cortical actin cytoskeleton organization; cortical microtubule organization; embryonic skeletal system morphogenesis; endothelial cell proliferation; establishment of centrosome localization; establishment or maintenance of epithelial cell apical/basal polarity; hard palate development; immunological synapse formation; lens development in camera-type eye; membrane raft organization; negative regulation of epithelial cell proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of mitotic cell cycle; negative regulation of p38MAPK cascade; negative regulation of protein kinase B signaling; negative regulation of T cell proliferation; negative regulation of transcription by RNA polymerase II; neurotransmitter receptor localization to postsynaptic specialization membrane; peristalsis; positive regulation of actin filament polymerization; positive regulation of cell proliferation; positive regulation of developmental growth; positive regulation of multicellular organism growth; positive regulation of potassium ion transport; positive regulation of protein localization to plasma membrane; protein localization; protein localization to plasma membrane; receptor clustering; receptor localization to synapse; regulation of cell shape; regulation of membrane potential; regulation of myelination; regulation of potassium ion export across plasma membrane; regulation of potassium ion import; regulation of protein localization; regulation of ventricular cardiac muscle cell action potential; regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; reproductive structure development; smooth muscle tissue development; T cell activation; T cell cytokine production; tissue morphogenesis; ureteric bud development
Reference #:  Q811D0 (UniProtKB)
Alt. Names/Synonyms: B130052P05Rik; discs, large homolog 1 (Drosophila); Disks large homolog 1; Dlg1; Dlgh1; E-dlg/SAP97; Embryo-dlg/synapse-associated protein 97; KIAA4187; mKIAA4187; OTTMUSP00000017432; SAP-97; SAP97; Synapse-associated protein 97
Gene Symbols: Dlg1
Molecular weight: 100,120 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene