the human homologue of the Drosophila discs large tumor suppressor is an essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Interacts through its guanylate kinase-like domain with DLGAP1/2/3/4, and MAP1A. May interact with PTEN, HTR2A and LRFN1. Interacts through its PDZ domains with NMDAR2A, KV1.1, KV1.2, KV1.3, KV1.4, KV1.5, GLUR1, GPR124 and GPR125. Interacts with cytoskeleton-associated proteins EPB41 and EZR. Found in a complex with KV1.5 and CAV3. Found in a complex with APC and CTNNB1. Interacts with CDH1 through binding to PIK3R1. Forms multiprotein complexes with CASK, LIN7A, LIN7B, LIN7C, APBA1, and KCNJ12. Interacts through its guanylate kinase-like domain with KIF13B. Forms a tripartite complex composed of DLG1, MPP7 and LIN7A/C. May interact with TJAP1. Interacts with TOPK and the HTLV-1 viral Tax and HPV-18 E6 papillomavirus (HPV) oncoproteins. The alternatively spliced domain I3 corresponding to amino acids (636-669) of isoform 4 is an EPB41 binding site mediating association to membranes in polarized and non-polarized cells. The PDZ domains may also mediate association to membranes by binding to EPB41 and GPR124 together with the L27 domain that binds CASK and DLG2. The L27 domain may regulate DLG1 self-association. The N-terminal alternatively spliced region is capable of binding several SH3 domains and also moderates the level of protein oligomerization. Processes such as wound healing and tissue maintenance dictate that cells maintain dynamic control of junction assembly and disassembly. Many pathologic processes such as cancer and invasion of host cells by microbes affect these pathways. The HPV-18 E6 oncogene sequesters INADL and its paralog MPDZ as well as DLG1 and targets them for degradation, contributing to loss of polarity. Seven human isoforms produced by alternative splicing have been described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Molecular Function: ion channel binding; ionotropic glutamate receptor binding; kinase binding; kinesin binding; L27 domain binding; mitogen-activated protein kinase kinase binding; molecular adaptor activity; PDZ domain binding; phosphatase binding; potassium channel regulator activity; protein binding; protein C-terminus binding; protein kinase binding; structural constituent of postsynaptic density
Biological Process: actin filament organization; activation of protein kinase activity; amyloid precursor protein metabolic process; astral microtubule organization; bicellular tight junction assembly; branching involved in ureteric bud morphogenesis; cell-cell adhesion; cellular protein-containing complex localization; chemical synaptic transmission; cortical actin cytoskeleton organization; cortical microtubule organization; embryonic skeletal system morphogenesis; endothelial cell proliferation; establishment of centrosome localization; establishment or maintenance of epithelial cell apical/basal polarity; hard palate development; immunological synapse formation; lens development in camera-type eye; membrane raft organization; negative regulation of epithelial cell proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of mitotic cell cycle; negative regulation of p38MAPK cascade; negative regulation of protein kinase B signaling; negative regulation of T cell proliferation; negative regulation of transcription by RNA polymerase II; neurotransmitter receptor localization to postsynaptic specialization membrane; peristalsis; positive regulation of actin filament polymerization; positive regulation of cell proliferation; positive regulation of developmental growth; positive regulation of multicellular organism growth; positive regulation of potassium ion transport; positive regulation of protein localization to plasma membrane; protein localization; protein localization to plasma membrane; receptor clustering; receptor localization to synapse; regulation of cell shape; regulation of membrane potential; regulation of myelination; regulation of potassium ion export across plasma membrane; regulation of potassium ion import; regulation of protein localization; regulation of ventricular cardiac muscle cell action potential; regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; reproductive structure development; smooth muscle tissue development; T cell activation; T cell cytokine production; tissue morphogenesis; ureteric bud development