IGFBP1 IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 7p12.3
Cellular Component:  endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi apparatus
Molecular Function:  insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding; protein binding; signaling receptor binding
Biological Process:  insulin receptor signaling pathway; multicellular organism aging; negative regulation of canonical Wnt signaling pathway; positive regulation of cell growth; regulation of insulin-like growth factor receptor signaling pathway; response to organic cyclic compound; signal transduction; tissue regeneration
Reference #:  P08833 (UniProtKB)
Alt. Names/Synonyms: AFBP; alpha-pregnancy-associated endometrial globulin; amniotic fluid binding protein; binding protein-25; binding protein-26; binding protein-28; growth hormone independent-binding protein; hIGFBP-1; IBP-1; IBP1; IGF-binding protein 1; IGF-BP25; IGFBP-1; IGFBP1; insulin like growth factor binding protein 1; insulin-like growth factor binding protein 1; Insulin-like growth factor-binding protein 1; Placental protein 12; PP12
Gene Symbols: IGFBP1
Molecular weight: 27,904 Da
Basal Isoelectric point: 5.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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IGFBP1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB