ITIH1 May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells. Belongs to the ITIH family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3p21.1
Cellular Component:  extracellular region
Molecular Function:  calcium ion binding; serine-type endopeptidase inhibitor activity
Biological Process:  hyaluronan metabolic process; negative regulation of endopeptidase activity
Reference #:  P19827 (UniProtKB)
Alt. Names/Synonyms: H1P; IATIH; IGHEP1; inter-alpha (globulin) inhibitor H1; inter-alpha (globulin) inhibitor, H1 polypeptide; Inter-alpha-inhibitor heavy chain 1; Inter-alpha-trypsin inhibitor complex component III; inter-alpha-trypsin inhibitor heavy chain 1; Inter-alpha-trypsin inhibitor heavy chain H1; ITI heavy chain H1; ITI-HC1; ITIH; ITIH1; MGC126415; Serum-derived hyaluronan-associated protein; SHAP
Gene Symbols: ITIH1
Molecular weight: 101,389 Da
Basal Isoelectric point: 6.31  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein