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MVK
Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.1.36; Kinase, other; RNA-binding; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Translation |
| Chromosomal Location of human Ortholog: 12q24.11 |
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Cellular Component:
cytosol; peroxisome
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Molecular Function:
ATP binding; identical protein binding; magnesium ion binding; mevalonate kinase activity; protein binding
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Biological Process:
cholesterol biosynthetic process; isopentenyl diphosphate biosynthetic process, mevalonate pathway; isoprenoid biosynthetic process; negative regulation of inflammatory response; phosphorylation; regulation of cholesterol biosynthetic process
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Disease: Hyper-igd Syndrome; Mevalonic Aciduria; Porokeratosis 3, Disseminated Superficial Actinic Type
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Reference #:
Q03426
(UniProtKB)
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Alt. Names/Synonyms: FLJ96772; KIME; LH receptor mRNA-binding protein; LRBP; Mevalonate kinase; mevalonate kinase 1; MK; MVK; MVLK; POROK3
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Gene Symbols: MVK
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Molecular weight:
42,451 Da
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Basal Isoelectric point:
6.02
Predict pI for various phosphorylation states
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