MVK Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.1.36; Kinase, other; RNA-binding; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Translation
Chromosomal Location of human Ortholog: 12q24.11
Cellular Component:  cytosol; peroxisome
Molecular Function:  ATP binding; identical protein binding; magnesium ion binding; mevalonate kinase activity; protein binding
Biological Process:  cholesterol biosynthetic process; isopentenyl diphosphate biosynthetic process, mevalonate pathway; isoprenoid biosynthetic process; negative regulation of inflammatory response; phosphorylation; regulation of cholesterol biosynthetic process
Disease: Hyper-igd Syndrome; Mevalonic Aciduria; Porokeratosis 3, Disseminated Superficial Actinic Type
Reference #:  Q03426 (UniProtKB)
Alt. Names/Synonyms: FLJ96772; KIME; LH receptor mRNA-binding protein; LRBP; Mevalonate kinase; mevalonate kinase 1; MK; MVK; MVLK; POROK3
Gene Symbols: MVK
Molecular weight: 42,451 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
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MVK

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene