CDK5 a protein kinase of the CDK family. Unlike other members of this family, it is not activated by cyclins but by p35 (CDK5R1) and p39. An important regulator of neuronal positioning during brain development. May also play a role in synaptogenesis and neurotransmission. Substrates include TAU, MAP2, NF-H and -M, Nudel, PDE6, beta-catenin, amphyphysin, dynamin I, synapsin 1, Munc-18, and NMDA receptor 2A. Plays a role in myogenesis, haematopoietic cell differentiation, spermatogenesis, insulin secretion, and lens differentiation. Implicated in the pathology of neurofibrillary tangles and formation of senile plaques, hallmarks of Alzheimer?s disease. Induces tau phosphorylation and aggregation and neurofibrillary tangle deposition and neurodegeneration in in vitro and in vivo animal models. Brain samples from Alzeimer?s pateints show elevated CDK5 activity. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CDK5 subfamily; CDK5 subfamily; CMGC group; Cell cycle regulation; EC; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Cellular Component:  axon; cell junction; cytoplasm; cytosol; dendrite; filopodium; growth cone; lamellipodium; membrane; neuromuscular junction; neuronal cell body; nucleus; perikaryon; postsynaptic density; postsynaptic membrane
Molecular Function:  acetylcholine receptor activator activity; ATP binding; cyclin-dependent protein serine/threonine kinase activity; ErbB-2 class receptor binding; ErbB-3 class receptor binding; histone kinase activity; Hsp90 protein binding; kinase activity; p53 binding; protein serine/threonine kinase activity; tau-protein kinase activity
Biological Process:  axonogenesis; behavioral response to cocaine; calcium ion import; cell cycle; cell division; cell migration; cell-matrix adhesion; central nervous system neuron development; cerebellar cortex formation; corpus callosum development; dendrite morphogenesis; excitatory postsynaptic potential; hippocampus development; histone phosphorylation; intracellular protein transport; layer formation in cerebral cortex; motor neuron axon guidance; negative regulation of axon extension; negative regulation of cell cycle; negative regulation of neuron death; negative regulation of protein export from nucleus; negative regulation of protein ubiquitination; negative regulation of proteolysis; negative regulation of synaptic plasticity; negative regulation of transcription, DNA-templated; neuron differentiation; neuron migration; neuron projection development; oligodendrocyte differentiation; peptidyl-threonine phosphorylation; positive regulation of calcium ion-dependent exocytosis; positive regulation of neuron apoptotic process; positive regulation of protein binding; positive regulation of protein kinase activity; positive regulation of protein targeting to membrane; positive regulation of signaling receptor activity; protein localization to synapse; receptor catabolic process; receptor clustering; regulation of cell migration; regulation of dendritic spine morphogenesis; regulation of protein localization to plasma membrane; regulation of synaptic plasticity; regulation of synaptic transmission, glutamatergic; rhythmic process; Schwann cell development; sensory perception of pain; serine phosphorylation of STAT protein; skeletal muscle tissue development; synapse assembly; synaptic transmission, dopaminergic; synaptic transmission, glutamatergic; visual learning
Reference #:  Q02399 (UniProtKB)
Alt. Names/Synonyms: CDK5; Cell division protein kinase 5; Cyclin-dependent-like kinase 5; PDPK; Proline-directed protein kinase 33 kDa subunit; Tau protein kinase II catalytic subunit; TPKII catalytic subunit
Gene Symbols: CDK5
Molecular weight: 33,288 Da
Basal Isoelectric point: 7.57  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
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Cross-references to other databases:  STRING  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein