LHR Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Gonadal and thyroid cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 2p16.3
Cellular Component:  endoplasmic reticulum; endosome; extracellular space; lysosome; nucleus; plasma membrane; receptor complex
Molecular Function:  ATPase binding; choriogonadotropin hormone binding; choriogonadotropin hormone receptor activity; G protein-coupled peptide receptor activity; identical protein binding; luteinizing hormone receptor activity; peptide hormone binding
Biological Process:  activation of adenylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; arachidonic acid secretion; cellular response to gonadotropin stimulus; cellular response to luteinizing hormone stimulus; central nervous system development; cognition; development of secondary male sexual characteristics; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; hormone-mediated signaling pathway; luteinizing hormone signaling pathway; male genitalia development; male gonad development; ovarian follicle development; ovulation cycle process; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of calcium ion transport into cytosol; positive regulation of calcium-mediated signaling; positive regulation of hormone biosynthetic process; positive regulation of inositol trisphosphate biosynthetic process; positive regulation of release of sequestered calcium ion into cytosol; protein targeting to lysosome; regulation of steroid hormone biosynthetic process; response to xenobiotic stimulus; seminiferous tubule development; spermatogenesis; uterus development
Disease: Leydig Cell Hypoplasia, Type I; Precocious Puberty, Male-limited
Reference #:  P22888 (UniProtKB)
Alt. Names/Synonyms: FLJ41504; HHG; hypergonadotropic hypogonadism; LCGR; LGR2; LH/CG-R; LH/CGR; LHCGR; LHR; LHRHR; LSH-R; LSHR; Luteinizing hormone receptor; luteinizing hormone/choriogonadotropin receptor; Lutropin-choriogonadotropic hormone receptor; lutropin/choriogonadotropin receptor; ULG5
Gene Symbols: LHCGR
Molecular weight: 78,643 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
Select Structure to View Below

LHR

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene