LHR Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Gonadal and thyroid cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 2p16.3
Cellular Component:  endosome; integral component of plasma membrane; plasma membrane
Molecular Function:  choriogonadotropin hormone binding; choriogonadotropin hormone receptor activity; luteinizing hormone receptor activity
Biological Process:  activation of adenylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular response to gonadotropin stimulus; cellular response to luteinizing hormone stimulus; cognition; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; luteinizing hormone signaling pathway; male genitalia development; male gonad development; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of inositol trisphosphate biosynthetic process
Disease: Leydig Cell Hypoplasia, Type I; Precocious Puberty, Male-limited
Reference #:  P22888 (UniProtKB)
Alt. Names/Synonyms: FLJ41504; HHG; LCGR; LGR2; LH/CG-R; LH/CGR; LHCGR; LHR; LHRHR; LSH-R; LSHR; Luteinizing hormone receptor; luteinizing hormone/choriogonadotropin receptor; Lutropin-choriogonadotropic hormone receptor; lutropin/choriogonadotropin receptor; ULG5
Gene Symbols: LHCGR
Molecular weight: 78,643 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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