LANP-L Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. Belongs to the ANP32 family. Expressed in peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit; Vesicle
Chromosomal Location of Human Ortholog: 3|3 F2.1
Cellular Component:  cytoplasm; cytoplasmic vesicle; nucleus
Molecular Function:  histone binding; phosphatase inhibitor activity
Biological Process:  chromatin organization; histone exchange
Reference #:  P97822 (UniProtKB)
Alt. Names/Synonyms: 2810018A15Rik; acidic (leucine-rich) nuclear phosphoprotein 32 family, member E; Acidic leucine-rich nuclear phosphoprotein 32 family member E; AI047746; AI326868; AN32E; Anp32e; Cerebellar postnatal development protein 1; CPD; Cpd1; LANP-L; LANP-like protein; LANPL; MGC11640; mLANP-L
Gene Symbols: Anp32e
Molecular weight: 29,622 Da
Basal Isoelectric point: 3.77  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene