calponin 2 Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. Belongs to the calponin family. Heart and smooth muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 10|10 C1
Cellular Component:  actin cytoskeleton; stress fiber
Molecular Function:  actin binding; actin filament binding; calmodulin binding
Biological Process:  actin filament organization; actomyosin structure organization; cellular response to mechanical stimulus; establishment of localization in cell; hemopoiesis; macrophage migration; negative regulation of macrophage migration; negative regulation of phagocytosis; phagocytosis; positive regulation of gene expression; regulation of actin filament-based process; regulation of leukocyte proliferation; wound healing
Reference #:  Q08093 (UniProtKB)
Alt. Names/Synonyms: AA408047; AI324678; Calpo2; calponin 2; Calponin H2, smooth muscle; Calponin-2; Cnn2; h2-c; h2-calponin; Neutral calponin; OTTMUSP00000020660
Gene Symbols: Cnn2
Molecular weight: 33,156 Da
Basal Isoelectric point: 7.53  Predict pI for various phosphorylation states
Select Structure to View Below

calponin 2

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein