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calponin 3
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. Belongs to the calponin family. Expressed in both non-smooth muscle tissues as well as smooth muscle tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 3|3 G1 |
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Cellular Component:
actin cytoskeleton; cytosol; dendrite; dendritic spine; neuronal cell body; postsynaptic density
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Molecular Function:
actin binding; calmodulin binding; microtubule binding; protein binding
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Biological Process:
actomyosin structure organization; negative regulation of ATPase activity
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Reference #:
Q9DAW9
(UniProtKB)
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Alt. Names/Synonyms: 1600014M03Rik; C85854; Calpo3; calponin 3; calponin 3, acidic; Calponin, acidic isoform; Calponin-3; Cnn3
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Gene Symbols: Cnn3
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Molecular weight:
36,429 Da
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Basal Isoelectric point:
5.46
Predict pI for various phosphorylation states
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