DDEF2 Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12|12 A1.2-A1.3
Cellular Component:  cytoplasm; Golgi apparatus; membrane; plasma membrane
Molecular Function:  GTPase activator activity; metal ion binding
Biological Process:  positive regulation of GTPase activity
Reference #:  Q7SIG6 (UniProtKB)
Alt. Names/Synonyms: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; Asap2; Ddef2; development and differentiation enhancing factor 2; Development and differentiation-enhancing factor 2; Gm1523; Gm592; MGC90837; PAG3; PAP; Paxillin-associated protein with ARF GAP activity 3; PYK2 C terminus-associated protein; Pyk2 C-terminus-associated protein
Gene Symbols: Asap2
Molecular weight: 106,805 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
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DDEF2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene