DDEF2 Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration. Detected in heart, brain, placenta, kidney, monocytes and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 12|12 A1.2-A1.3
Cellular Component:  cytoplasm; Golgi apparatus; membrane; plasma membrane
Molecular Function:  GTPase activator activity; metal ion binding
Biological Process:  positive regulation of GTPase activity
Reference #:  Q7SIG6 (UniProtKB)
Alt. Names/Synonyms: 6530401G17Rik; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; Asap2; Ddef2; development and differentiation enhancing factor 2; Development and differentiation-enhancing factor 2; Gm1523; Gm592; MGC90837; PAG3; PAP; Paxillin-associated protein with ARF GAP activity 3; PYK2 C terminus-associated protein; Pyk2 C-terminus-associated protein
Gene Symbols: Asap2
Molecular weight: 106,805 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
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DDEF2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene