ANK3 In skeletal muscle, required for costamere localization of DMD and betaDAG1. Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption. Isoform 5: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. Expressed in brain, neurons, muscles and other tissues. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 10 B5.3|10 36.1 cM
Cellular Component:  axon; axon initial segment; basal plasma membrane; basolateral plasma membrane; cell junction; cell projection; cell surface; cytoplasm; cytoskeleton; dendrite; intercalated disc; lateral plasma membrane; lysosome; membrane; neuromuscular junction; neuron projection; node of Ranvier; paranode region of axon; plasma membrane; postsynaptic membrane; sarcolemma; sarcoplasmic reticulum; spectrin-associated cytoskeleton; synapse; T-tubule; Z disc
Molecular Function:  cadherin binding; cytoskeletal protein binding; ion channel binding; phosphorylation-dependent protein binding; protein binding; protein binding, bridging; spectrin binding; structural constituent of cytoskeleton
Biological Process:  axon guidance; axonogenesis; cellular response to magnesium ion; clustering of voltage-gated sodium channels; establishment of protein localization; Golgi to plasma membrane protein transport; magnesium ion homeostasis; maintenance of protein location in plasma membrane; membrane assembly; mitotic cytokinesis; negative regulation of delayed rectifier potassium channel activity; neuronal action potential; plasma membrane organization; positive regulation of action potential; positive regulation of cation channel activity; positive regulation of cell communication by electrical coupling; positive regulation of gene expression; positive regulation of homotypic cell-cell adhesion; positive regulation of membrane depolarization during cardiac muscle cell action potential; positive regulation of membrane potential; positive regulation of protein targeting to membrane; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; protein localization to axon; protein localization to plasma membrane; regulation of potassium ion transport; signal transduction; synapse organization
Reference #:  G5E8K5 (UniProtKB)
Alt. Names/Synonyms: 2900054D09Rik; AI314020; Ank; Ank-3; Ank3; AnkG; Anky; Ankyrin 3; ankyrin 3, epithelial; Ankyrin-3; Ankyrin-G; brain-specific ankyrin-G; MGC14049
Gene Symbols: Ank3
Molecular weight: 214,062 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein