LANP-L Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. Belongs to the ANP32 family. Expressed in peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit; Vesicle
Chromosomal Location of human Ortholog: 1q21.2
Cellular Component:  cytoplasmic vesicle; nucleus; Swr1 complex
Molecular Function:  histone binding; histone chaperone activity; phosphatase inhibitor activity; protein binding; protein folding chaperone
Biological Process:  chromatin organization; negative regulation of catalytic activity; protein folding; regulation of apoptotic process
Reference #:  Q9BTT0 (UniProtKB)
Alt. Names/Synonyms: acidic (leucine-rich) nuclear phosphoprotein 32 family, member E; Acidic leucine-rich nuclear phosphoprotein 32 family member E; acidic nuclear phosphoprotein 32 family member E; AN32E; ANP32E; LANP-L; LANP-like protein; LANPL; leucine-rich acidic nuclear protein like; MGC5350
Gene Symbols: ANP32E
Molecular weight: 30,692 Da
Basal Isoelectric point: 3.77  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein