Tara May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover. Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal brain, retina and cochlea but is not detectable in the other tissues. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 22q13.1
Cellular Component:  actin cytoskeleton; cytoplasm; microtubule organizing center; midbody; nucleus; stereocilium base
Molecular Function:  actin filament binding; myosin II binding; small GTPase binding; ubiquitin protein ligase binding
Biological Process:  actin filament organization; actin modification; auditory receptor cell stereocilium organization; barbed-end actin filament capping; cell cycle; cell division; positive regulation of substrate adhesion-dependent cell spreading; sensory perception of sound
Disease: Deafness, Autosomal Recessive 28
Reference #:  Q9H2D6 (UniProtKB)
Alt. Names/Synonyms: DFNB28; dJ37E16.4; FLJ39315; HRIHFB2122; KIAA1662; Protein Tara; TAP68; TARA; Tara isoform 2; tara-like protein; TRIO and F-actin binding protein; TRIO and F-actin-binding protein; Trio-associated repeat on actin; TRIOBP; TRIOBP-6
Gene Symbols: TRIOBP
Molecular weight: 261,376 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein