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Tara
May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover. Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal brain, retina and cochlea but is not detectable in the other tissues. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 22q13.1 |
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Cellular Component:
actin cytoskeleton; cytoplasm; microtubule organizing center; midbody; nucleus; stereocilium base
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Molecular Function:
actin filament binding; myosin II binding; small GTPase binding; ubiquitin protein ligase binding
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Biological Process:
actin filament organization; actin modification; auditory receptor cell stereocilium organization; barbed-end actin filament capping; cell cycle; cell division; positive regulation of substrate adhesion-dependent cell spreading; sensory perception of sound
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Disease: Deafness, Autosomal Recessive 28
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Reference #:
Q9H2D6
(UniProtKB)
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Alt. Names/Synonyms: DFNB28; dJ37E16.4; FLJ39315; HRIHFB2122; KIAA1662; Protein Tara; TAP68; TARA; Tara isoform 2; tara-like protein; TRIO and F-actin binding protein; TRIO and F-actin-binding protein; Trio-associated repeat on actin; TRIOBP; TRIOBP-6
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Gene Symbols: TRIOBP
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Molecular weight:
261,376 Da
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Basal Isoelectric point:
8.86
Predict pI for various phosphorylation states
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