calponin 2 Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. Belongs to the calponin family. Heart and smooth muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  cell-cell junction; cytoskeleton; extracellular region; specific granule lumen; stress fiber; tertiary granule lumen
Molecular Function:  actin binding; calmodulin binding
Biological Process:  actomyosin structure organization; cellular response to mechanical stimulus; cytoskeleton organization; interleukin-12-mediated signaling pathway; neutrophil degranulation; regulation of actin filament-based process
Reference #:  Q99439 (UniProtKB)
Alt. Names/Synonyms: calponin 2; Calponin H2, smooth muscle; Calponin-2; CNN2; Neutral calponin
Gene Symbols: CNN2
Molecular weight: 33,697 Da
Basal Isoelectric point: 6.94  Predict pI for various phosphorylation states
Select Structure to View Below

calponin 2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein