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DLG3
Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. Belongs to the MAGUK family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of Human Ortholog: Xq13.1 |
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Cellular Component:
AMPA glutamate receptor complex; bicellular tight junction; cytosol; dendritic shaft; glutamatergic synapse; growth cone; neuronal cell body; plasma membrane; postsynaptic density, intracellular component
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Molecular Function:
kinase binding; PDZ domain binding; phosphatase binding; protein binding; protein C-terminus binding; protein phosphatase binding; structural constituent of postsynaptic density; ubiquitin protein ligase binding
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Biological Process:
establishment of planar polarity; maintenance of postsynaptic density structure; MAPK cascade; negative regulation of cell proliferation; negative regulation of phosphatase activity; positive regulation of protein tyrosine kinase activity; regulation of NMDA receptor activity; regulation of postsynaptic membrane neurotransmitter receptor levels
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Disease: Mental Retardation, X-linked 90
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Reference #:
Q92796
(UniProtKB)
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Alt. Names/Synonyms: discs large MAGUK scaffold protein 3; discs, large homolog 3; discs, large homolog 3 (Drosophila); Disks large homolog 3; DLG3; KIAA1232; MRX; MRX90; NEDLG; Neuroendocrine-DLG; PPP1R82; protein phosphatase 1, regulatory subunit 82; SAP-102; SAP102; Synapse-associated protein 102; XLMR
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Gene Symbols: DLG3
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Molecular weight:
90,314 Da
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Basal Isoelectric point:
6.56
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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