DLG3 Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. Belongs to the MAGUK family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component:  AMPA glutamate receptor complex; bicellular tight junction; cytosol; dendritic shaft; glutamatergic synapse; growth cone; neuronal cell body; plasma membrane; postsynaptic density, intracellular component
Molecular Function:  kinase binding; PDZ domain binding; phosphatase binding; protein binding; protein C-terminus binding; protein phosphatase binding; structural constituent of postsynaptic density; ubiquitin protein ligase binding
Biological Process:  establishment of planar polarity; maintenance of postsynaptic density structure; MAPK cascade; negative regulation of cell proliferation; negative regulation of phosphatase activity; positive regulation of protein tyrosine kinase activity; regulation of NMDA receptor activity; regulation of postsynaptic membrane neurotransmitter receptor levels
Disease: Mental Retardation, X-linked 90
Reference #:  Q92796 (UniProtKB)
Alt. Names/Synonyms: discs large MAGUK scaffold protein 3; discs, large homolog 3; discs, large homolog 3 (Drosophila); Disks large homolog 3; DLG3; KIAA1232; MRX; MRX90; NEDLG; Neuroendocrine-DLG; PPP1R82; protein phosphatase 1, regulatory subunit 82; SAP-102; SAP102; Synapse-associated protein 102; XLMR
Gene Symbols: DLG3
Molecular weight: 90,314 Da
Basal Isoelectric point: 6.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein