DLG3 Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. Interacts through its PDZ domains with NETO1, GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4. Interacts through its PDZ domains with APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Belongs to the MAGUK family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component:  AMPA glutamate receptor complex; bicellular tight junction; cytosol; dendritic shaft; glutamatergic synapse; growth cone; neuronal cell body; plasma membrane; postsynaptic density, intracellular component
Molecular Function:  kinase binding; PDZ domain binding; phosphatase binding; protein binding; protein C-terminus binding; protein phosphatase binding; structural constituent of postsynaptic density; ubiquitin protein ligase binding
Biological Process:  establishment of planar polarity; maintenance of postsynaptic density structure; MAPK cascade; negative regulation of cell proliferation; negative regulation of phosphatase activity; positive regulation of protein tyrosine kinase activity; regulation of NMDA receptor activity; regulation of postsynaptic membrane neurotransmitter receptor levels
Disease: Mental Retardation, X-linked 90
Reference #:  Q92796 (UniProtKB)
Alt. Names/Synonyms: discs, large homolog 3 (Drosophila); Disks large homolog 3; DLG3; KIAA1232; MRX; MRX90; NEDLG; Neuroendocrine-DLG; SAP-102; SAP102; Synapse-associated protein 102; XLMR
Gene Symbols: DLG3
Molecular weight: 90,314 Da
Basal Isoelectric point: 6.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein