calponin 3 Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. Belongs to the calponin family. Expressed in both non-smooth muscle tissues as well as smooth muscle tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 1p21.3
Cellular Component:  actin cytoskeleton; cytosol; dendritic spine; glutamatergic synapse; neuronal cell body
Molecular Function:  actin filament binding; calmodulin binding; microtubule binding
Biological Process:  actin filament organization; actomyosin structure organization; cell-cell adhesion; epithelial cell differentiation; negative regulation of ATP-dependent activity
Reference #:  Q15417 (UniProtKB)
Alt. Names/Synonyms: calponin 3; calponin 3, acidic; Calponin, acidic isoform; Calponin-3; CNN3; dJ639P13.2.2 (acidic calponin 3)
Gene Symbols: CNN3
Molecular weight: 36,414 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
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calponin 3

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein