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ARHGEF5
Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1. Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation. Involved in positive regulation of immature dendritic cell migration. Ubiquitously expressed with highest levels in placenta. High levels are also found in colon, kidney, trachea, prostate, liver, pancreas, pituitary gland, thyroid gland and mammary gland. In fetal tissues, expressed at high levels in kidney, lung and liver (PubMed:15601624). Expressed at low levels in lung and heart (PubMed:14662653). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein |
| Chromosomal Location of human Ortholog: 7q35 |
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Cellular Component:
anchoring junction; cell periphery; cell projection; cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane; podosome
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Molecular Function:
GTP binding; guanyl-nucleotide exchange factor activity; lipid binding; protein binding
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Biological Process:
actin cytoskeleton organization; activation of GTPase activity; hematopoietic stem cell homeostasis; intracellular signal transduction; myeloid dendritic cell chemotaxis; positive regulation of DNA-binding transcription factor activity; positive regulation of JUN kinase activity; positive regulation of podosome assembly; positive regulation of protein import; positive regulation of stress fiber assembly; regulation of actin cytoskeleton organization; regulation of cytoskeleton organization; regulation of ERK1 and ERK2 cascade; regulation of GTPase activity; regulation of small GTPase mediated signal transduction
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Reference #:
Q12774
(UniProtKB)
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Alt. Names/Synonyms: ARHG5; ARHGEF5; DKFZp686N1969; Ephexin-3; ephexin3; GEF5; Guanine nucleotide regulatory protein TIM; Oncogene TIM; P60; p60 TIM; Rho guanine nucleotide exchange factor (GEF) 5; Rho guanine nucleotide exchange factor 5; TIM; TIM1; Transforming immortalized mammary oncogene
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Gene Symbols: ARHGEF5
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Molecular weight:
176,800 Da
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Basal Isoelectric point:
5.37
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Microtubule Dynamics
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