ARHGEF5 Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1. Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation. Involved in positive regulation of immature dendritic cell migration. Ubiquitously expressed with highest levels in placenta. High levels are also found in colon, kidney, trachea, prostate, liver, pancreas, pituitary gland, thyroid gland and mammary gland. In fetal tissues, expressed at high levels in kidney, lung and liver (PubMed:15601624). Expressed at low levels in lung and heart (PubMed:14662653). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 7q35
Cellular Component:  cell junction; cell periphery; cell projection; cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane; podosome
Molecular Function:  GTP binding; guanyl-nucleotide exchange factor activity; lipid binding; protein binding; Rho guanyl-nucleotide exchange factor activity
Biological Process:  actin cytoskeleton organization; G protein-coupled receptor signaling pathway; intracellular signal transduction; myeloid dendritic cell chemotaxis; positive regulation of apoptotic process; positive regulation of DNA-binding transcription factor activity; positive regulation of GTPase activity; positive regulation of JUN kinase activity; positive regulation of podosome assembly; positive regulation of protein import; positive regulation of stress fiber assembly; regulation of actin cytoskeleton organization; regulation of cytoskeleton organization; regulation of GTPase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction
Reference #:  Q12774 (UniProtKB)
Alt. Names/Synonyms: ARHG5; ARHGEF5; DKFZp686N1969; Ephexin-3; ephexin3; GEF5; Guanine nucleotide regulatory protein TIM; Oncogene TIM; P60; p60 TIM; Rho guanine nucleotide exchange factor (GEF) 5; Rho guanine nucleotide exchange factor 5; TIM; TIM1; Transforming immortalized mammary oncogene
Gene Symbols: ARHGEF5
Molecular weight: 176,800 Da
Basal Isoelectric point: 5.37  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene