ARHGEF5 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 7q35
Cellular Component:  cell junction; cell periphery; cell projection; cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane; podosome
Molecular Function:  GTP binding; guanyl-nucleotide exchange factor activity; lipid binding; protein binding; Rho guanyl-nucleotide exchange factor activity
Biological Process:  actin cytoskeleton organization; G protein-coupled receptor signaling pathway; intracellular signal transduction; myeloid dendritic cell chemotaxis; positive regulation of apoptotic process; positive regulation of DNA-binding transcription factor activity; positive regulation of GTPase activity; positive regulation of JUN kinase activity; positive regulation of podosome assembly; positive regulation of protein import; positive regulation of stress fiber assembly; regulation of actin cytoskeleton organization; regulation of cytoskeleton organization; regulation of GTPase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction
Reference #:  Q12774 (UniProtKB)
Alt. Names/Synonyms: ARHG5; ARHGEF5; DKFZp686N1969; GEF5; Guanine nucleotide regulatory protein TIM; Oncogene TIM; P60; p60 TIM; Rho guanine nucleotide exchange factor (GEF) 5; Rho guanine nucleotide exchange factor 5; TIM; TIM1; Transforming immortalized mammary oncogene
Gene Symbols: ARHGEF5
Molecular weight: 176,800 Da
Basal Isoelectric point: 5.37  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene