ARPP-19 Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. Belongs to the endosulfine family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 15q21.2
Cellular Component:  nucleoplasm
Molecular Function:  phosphatase inhibitor activity; potassium channel regulator activity; protein phosphatase 2A binding; protein phosphatase regulator activity; signaling receptor binding
Biological Process:  cell division; G2/M transition of mitotic cell cycle; mitotic cell cycle; negative regulation of phosphoprotein phosphatase activity; positive regulation of gluconeogenesis; positive regulation of glucose import
Reference #:  P56211 (UniProtKB)
Alt. Names/Synonyms: ARP19; ARPP-16; ARPP-19; ARPP16; ARPP19; cAMP-regulated phosphoprotein 19; cAMP-regulated phosphoprotein, 19kDa; cyclic AMP phosphoprotein, 19 kD; endosulfine alpha-like; ENSAL; FLJ41622
Gene Symbols: ARPP19
Molecular weight: 12,323 Da
Basal Isoelectric point: 9.07  Predict pI for various phosphorylation states
Select Structure to View Below

ARPP-19

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB