ARPP-19
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. Belongs to the endosulfine family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: Cell cycle regulation; Phosphatase, regulatory subunit |
Chromosomal Location of human Ortholog: 15q21.2 |
Cellular Component:
cytoplasm; nucleoplasm
|
Molecular Function:
phosphatase inhibitor activity; potassium channel regulator activity; protein binding; protein phosphatase 2A binding; protein phosphatase inhibitor activity; protein phosphatase regulator activity; signaling receptor binding
|
Biological Process:
cell division; G2/M transition of mitotic cell cycle; mitotic cell cycle; negative regulation of protein dephosphorylation; positive regulation of gluconeogenesis; positive regulation of glucose import
|
Reference #:
P56211
(UniProtKB)
|
Alt. Names/Synonyms: ARP19; ARPP-16; ARPP-19; ARPP16; ARPP19; cAMP regulated phosphoprotein 19; cAMP-regulated phosphoprotein 19; cAMP-regulated phosphoprotein 19kDa; cAMP-regulated phosphoprotein, 19kDa; cyclic AMP phosphoprotein, 19 kD; endosulfine alpha-like; ENSAL; FLJ41622
|
Gene Symbols: ARPP19
|
Molecular weight:
12,323 Da
|
Basal Isoelectric point:
9.07
Predict pI for various phosphorylation states
|