CTNNG Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. Belongs to the beta-catenin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component:  actin cytoskeleton; apicolateral plasma membrane; catenin complex; cell-cell adherens junction; cell-cell junction; cornified envelope; cytoplasm; cytoplasmic side of plasma membrane; cytoskeleton; cytosol; desmosome; extracellular region; fascia adherens; ficolin-1-rich granule lumen; gamma-catenin-TCF7L2 complex; intercalated disc; intermediate filament; lateral plasma membrane; nucleus; plasma membrane; protein-DNA complex; specific granule lumen; Z disc; zonula adherens
Molecular Function:  alpha-catenin binding; cadherin binding; cell adhesion molecule binding; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication; protein binding; protein homodimerization activity; protein kinase binding; protein phosphatase binding; structural constituent of cell wall; structural molecule activity; transcription coactivator activity
Biological Process:  adherens junction organization; bundle of His cell-Purkinje myocyte adhesion involved in cell communication; cell migration; cell-cell adhesion; cellular response to indole-3-methanol; cornification; cytoskeletal anchoring at plasma membrane; desmosome assembly; detection of mechanical stimulus; endothelial cell-cell adhesion; keratinization; negative regulation of blood vessel endothelial cell migration; neutrophil degranulation; positive regulation of angiogenesis; positive regulation of canonical Wnt signaling pathway; positive regulation of cell-matrix adhesion; positive regulation of DNA-binding transcription factor activity; positive regulation of protein import into nucleus; protein heterooligomerization; protein localization to plasma membrane; regulation of cell proliferation; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 12; Naxos Disease
Reference #:  P14923 (UniProtKB)
Alt. Names/Synonyms: ARVD12; catenin (cadherin-associated protein), gamma (80kD); catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; CTNNG; Desmoplakin III; Desmoplakin-3; DP3; DPIII; gamma-catenin; Junction plakoglobin; JUP; PDGB; PKGB; PLAK
Gene Symbols: JUP
Molecular weight: 81,745 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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