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ARRB1
an arrestin protein of the beta-arrestin protein family that function in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating receptor desensitization. Also play roles in receptor resensitization processes. Acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 11q13.4 |
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Cellular Component:
chromatin; clathrin-coated pit; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; Golgi membrane; lysosomal membrane; nuclear body; nucleoplasm; nucleus; plasma membrane; pseudopodium
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Molecular Function:
angiotensin receptor binding; arrestin family protein binding; enzyme inhibitor activity; G protein-coupled receptor binding; GTPase activator activity; histone acetyltransferase activity; insulin-like growth factor receptor binding; protein binding; transcription coactivator activity; ubiquitin protein ligase binding
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Biological Process:
G protein-coupled receptor internalization; negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; negative regulation of NF-kappaB transcription factor activity; negative regulation of Notch signaling pathway; negative regulation of protein ubiquitination; positive regulation of ERK1 and ERK2 cascade; positive regulation of histone acetylation; positive regulation of protein phosphorylation; positive regulation of receptor internalization; positive regulation of Rho protein signal transduction; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein transport; protein ubiquitination; regulation of transcription by RNA polymerase II; signal transduction; stress fiber assembly; ubiquitin-dependent protein catabolic process; visual perception
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Reference #:
P49407
(UniProtKB)
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Alt. Names/Synonyms: ARB1; ARR1; ARRB1; arrestin 2; arrestin beta 1; Arrestin beta-1; arrestin, beta 1; beta-arrestin; Beta-arrestin-1; Non-visual arrestin-2
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Gene Symbols: ARRB1
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Molecular weight:
47,066 Da
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Basal Isoelectric point:
5.84
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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Hedgehog Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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