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DLG1
Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. Belongs to the MAGUK family. Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Widely expressed, with isoforms displaying different expression profiles. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of rat Ortholog: 11q22 |
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Cellular Component:
apical plasma membrane; basal plasma membrane; basement membrane; basolateral plasma membrane; bicellular tight junction; cell junction; cell projection membrane; cell-cell junction; cytoplasm; cytoplasmic side of plasma membrane; cytosol; dendrite; endoplasmic reticulum; endoplasmic reticulum membrane; glutamatergic synapse; Golgi apparatus; immunological synapse; lateral loop; lateral plasma membrane; membrane raft; microtubule; microvillus; MPP7-DLG1-LIN7 complex; myelin sheath abaxonal region; neuromuscular junction; neuron projection; neuronal cell body; node of Ranvier; nucleus; paranode region of axon; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; postsynaptic density membrane; postsynaptic density, intracellular component; postsynaptic membrane; presynaptic membrane; synapse; synaptic membrane; synaptic vesicle membrane; T-tubule
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Molecular Function:
ionotropic glutamate receptor binding; kinase binding; kinesin binding; L27 domain binding; molecular adaptor activity; PDZ domain binding; phosphatase binding; potassium channel regulator activity; protein binding; protein kinase binding; structural constituent of postsynaptic density; transmembrane transporter binding
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Biological Process:
actin filament organization; actin filament polymerization; activation of protein kinase activity; amyloid precursor protein metabolic process; astral microtubule organization; bicellular tight junction assembly; branching involved in ureteric bud morphogenesis; cell adhesion; cell population proliferation; cell-cell adhesion; cellular response to brain-derived neurotrophic factor stimulus; cerebral cortex development; chemical synaptic transmission; cortical actin cytoskeleton organization; cortical microtubule organization; embryo development; embryonic skeletal system morphogenesis; endothelial cell proliferation; establishment of centrosome localization; establishment or maintenance of epithelial cell apical/basal polarity; hard palate development; immunological synapse formation; lens development in camera-type eye; maintenance of postsynaptic density structure; membrane raft organization; negative regulation of epithelial cell proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of p38MAPK cascade; negative regulation of protein kinase B signaling; negative regulation of T cell proliferation; negative regulation of transcription by RNA polymerase II; neurotransmitter receptor localization to postsynaptic specialization membrane; peristalsis; positive regulation of actin filament polymerization; positive regulation of cell population proliferation; positive regulation of gene expression; positive regulation of potassium ion transport; positive regulation of protein localization to plasma membrane; protein kinase B signaling; protein localization; protein localization to plasma membrane; protein-containing complex localization; receptor clustering; regulation of cell shape; regulation of membrane potential; regulation of myelination; regulation of NIK/NF-kappaB signaling; regulation of potassium ion export across plasma membrane; regulation of potassium ion import; regulation of protein localization; regulation of protein localization to synapse; regulation of ventricular cardiac muscle cell action potential; regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; reproductive structure development; smooth muscle tissue development; T cell activation; T cell proliferation; tissue morphogenesis; ureteric bud development
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Reference #:
Q62696
(UniProtKB)
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Alt. Names/Synonyms: discs, large homolog 1 (Drosophila); Disks large homolog 1; Dlg1; Dlgh1; Drosophila discs-large tumor suppressor homologue (synapse associated protein); SAP-97; SAP97; Synapse-associated protein 97
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Gene Symbols: Dlg1
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Molecular weight:
100,571 Da
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Basal Isoelectric point:
5.64
Predict pI for various phosphorylation states
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CST Pathways:
T Cell Receptor Signaling
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