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F3
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Belongs to the tissue factor family. Lung, placenta and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell surface; Membrane protein, integral |
| Chromosomal Location of mouse Ortholog: 3 G1|3 52.94 cM |
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Cellular Component:
cell surface; collagen-containing extracellular matrix; cytoplasm; extracellular space; membrane; plasma membrane; serine-type endopeptidase complex; serine-type peptidase complex
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Molecular Function:
cytokine receptor activity; phospholipid binding; protease binding; serine-type endopeptidase activity
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Biological Process:
activation of blood coagulation via clotting cascade; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of plasma proteins involved in acute inflammatory response; blood coagulation; blood coagulation, extrinsic pathway; blood coagulation, fibrin clot formation; blood coagulation, intrinsic pathway; cytokine-mediated signaling pathway; hemostasis; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; positive regulation of gene expression; positive regulation of interleukin-8 production; positive regulation of platelet-derived growth factor receptor signaling pathway; positive regulation of protein kinase B signaling; positive regulation of smooth muscle cell migration; protein processing; proteolysis; response to wounding
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Reference #:
P20352
(UniProtKB)
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Alt. Names/Synonyms: AA409063; CD142; Cf-3; Cf3; Coagulation factor III; F3; TF; Tissue factor
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Gene Symbols: F3
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Molecular weight:
32,935 Da
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Basal Isoelectric point:
9.4
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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