F3 Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Belongs to the tissue factor family. Lung, placenta and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of mouse Ortholog: 3 G1|3 52.94 cM
Cellular Component:  cell surface; collagen-containing extracellular matrix; cytoplasm; extracellular space; membrane; plasma membrane; serine-type endopeptidase complex; serine-type peptidase complex
Molecular Function:  cytokine receptor activity; phospholipid binding; protease binding; serine-type endopeptidase activity
Biological Process:  activation of blood coagulation via clotting cascade; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of plasma proteins involved in acute inflammatory response; blood coagulation; blood coagulation, extrinsic pathway; blood coagulation, fibrin clot formation; blood coagulation, intrinsic pathway; cytokine-mediated signaling pathway; hemostasis; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; positive regulation of gene expression; positive regulation of interleukin-8 production; positive regulation of platelet-derived growth factor receptor signaling pathway; positive regulation of protein kinase B signaling; positive regulation of smooth muscle cell migration; protein processing; proteolysis; response to wounding
Reference #:  P20352 (UniProtKB)
Alt. Names/Synonyms: AA409063; CD142; Cf-3; Cf3; Coagulation factor III; F3; TF; Tissue factor
Gene Symbols: F3
Molecular weight: 32,935 Da
Basal Isoelectric point: 9.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene