| F3 Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Belongs to the tissue factor family. Lung, placenta and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB. |
| Protein type: Cell surface; Membrane protein, integral |
| Chromosomal Location of human Ortholog: 1p21.3 |
| Cellular Component: cell surface; collagen-containing extracellular matrix; external side of plasma membrane; extracellular space; membrane; plasma membrane; serine-type peptidase complex |
| Molecular Function: cytokine receptor activity; phospholipid binding; protease binding; protein binding; serine-type endopeptidase activity |
| Biological Process: activation of blood coagulation via clotting cascade; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of plasma proteins involved in acute inflammatory response; blood coagulation; cytokine-mediated signaling pathway; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of gene expression; positive regulation of interleukin-8 production; positive regulation of platelet-derived growth factor receptor signaling pathway; positive regulation of positive chemotaxis; positive regulation of protein kinase B signaling; protein processing |
| Reference #: P13726 (UniProtKB) |
| Alt. Names/Synonyms: CD142; Coagulation factor III; coagulation factor III (thromboplastin, tissue factor); coagulation factor III, tissue factor; F3; TF; TFA; Thromboplastin; Tissue factor |
| Gene Symbols: F3 |
| Molecular weight: 33,068 Da |
| Basal Isoelectric point: 6.64 Predict pI for various phosphorylation states |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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F3 |
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| Cross-references to other databases:
AlphaFold
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STRING
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cBioPortal
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Wikipedia
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Reactome
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Protein Atlas
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BioGPS
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Pfam
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