F3 Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Belongs to the tissue factor family. Lung, placenta and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p21.3

Cellular Component: cell surface; collagen-containing extracellular matrix; extracellular space; integral component of membrane; intrinsic component of external side of plasma membrane; plasma membrane; serine-type peptidase complex

Molecular Function: phospholipid binding; protease binding; protein binding

Biological Process: activation of blood coagulation via clotting cascade; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of plasma proteins involved in acute inflammatory response; blood coagulation; blood coagulation, extrinsic pathway; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of platelet-derived growth factor receptor signaling pathway; positive regulation of positive chemotaxis; positive regulation of protein kinase B signaling; protein processing

Reference #: P13726 (UniProtKB)

Alt. Names/Synonyms: CD142; Coagulation factor III; coagulation factor III (thromboplastin, tissue factor); F3; TF; TFA; Thromboplastin; Tissue factor

Gene Symbols: F3

Molecular weight: 33,068 Da

Basal Isoelectric point: 6.64 Predict pI for various phosphorylation states

Protein-Specific Antibodies or siRNAs from Cell Signaling Technology^®

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F3

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