PDIA1 This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. Belongs to the protein disulfide isomerase family. Note: This description may include information from UniProtKB.
Protein type: EC 5.3.4.1; Endoplasmic reticulum; Isomerase; Nuclear receptor co-regulator; Oxidoreductase
Chromosomal Location of Human Ortholog: 11 E2|11 84.27 cM
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum chaperone complex; endoplasmic reticulum-Golgi intermediate compartment; external side of plasma membrane; membrane; plasma membrane; procollagen-proline 4-dioxygenase complex
Molecular Function:  enzyme binding; integrin binding; isomerase activity; peptide disulfide oxidoreductase activity; protein binding; protein disulfide isomerase activity; protein heterodimerization activity
Biological Process:  cell redox homeostasis; cellular response to hypoxia; cellular response to interleukin-7; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; positive regulation of viral entry into host cell; protein folding; regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; response to endoplasmic reticulum stress
Reference #:  P09103 (UniProtKB)
Alt. Names/Synonyms: Cellular thyroid hormone-binding protein; Endoplasmic reticulum resident protein 59; ER protein 59; ERp59; OTTMUSP00000004494; P4hb; p55; PDI; Pdia1; Prolyl 4-hydroxylase subunit beta; prolyl 4-hydroxylase, beta polypeptide; protein disulfide isomerase; Protein disulfide-isomerase; Thbp
Gene Symbols: P4hb
Molecular weight: 57,058 Da
Basal Isoelectric point: 4.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PDIA1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA