MIG-6 Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development. Belongs to the MIG6 family. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Tumor suppressor
Chromosomal Location of human Ortholog: 1p36.23
Cellular Component:  cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; nucleus
Molecular Function:  GTPase activator activity; protein binding; protein kinase binding; SH3 domain binding; small GTPase binding
Biological Process:  cellular hyperosmotic response; cellular response to dexamethasone stimulus; cellular response to epidermal growth factor stimulus; cellular response to insulin stimulus; cellular response to platelet-derived growth factor stimulus; lung alveolus development; lung epithelium development; lung vasculature development; negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of collagen biosynthetic process; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor-activated receptor activity; negative regulation of ERK1 and ERK2 cascade; negative regulation of interleukin-1 beta production; negative regulation of protein autophosphorylation; negative regulation of tumor necrosis factor production; regulation of keratinocyte differentiation; regulation of type B pancreatic cell proliferation; skin morphogenesis
Reference #:  Q9UJM3 (UniProtKB)
Alt. Names/Synonyms: ERBB receptor feedback inhibitor 1; ERRFI; ERRFI1; GENE-33; MIG-6; MIG6; Mitogen-inducible gene 6 protein; RALT; receptor-associated late transducer
Gene Symbols: ERRFI1
Molecular weight: 50,560 Da
Basal Isoelectric point: 8.38  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MIG-6

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene