EFS Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES. Belongs to the CAS family. The protein has been detected in lung and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 14|14 C2
Cellular Component:  cytoplasm; focal adhesion; plasma membrane
Molecular Function:  protein domain specific binding; SH3 domain binding
Biological Process:  cell adhesion; cell migration; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q64355 (UniProtKB)
Alt. Names/Synonyms: Efs; Embryonal Fyn-associated substrate; Signal-integrating protein; Sin; SRC-interacting protein
Gene Symbols: Efs
Molecular weight: 58,973 Da
Basal Isoelectric point: 5.02  Predict pI for various phosphorylation states
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EFS

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein