nAChRA3 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-3/CHRNA3 sub-subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 8q24
Cellular Component:  acetylcholine-gated channel complex; cell junction; cholinergic synapse; dendrite; dopaminergic synapse; integral component of plasma membrane; integral component of postsynaptic specialization membrane; membrane; neuron projection; neuronal cell body; plasma membrane raft; postsynaptic density; postsynaptic membrane; synapse
Molecular Function:  acetylcholine binding; acetylcholine receptor activity; acetylcholine-gated cation-selective channel activity; drug binding; protein heterodimerization activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process:  acetylcholine receptor signaling pathway; activation of transmembrane receptor protein tyrosine kinase activity; behavioral response to nicotine; chemical synaptic transmission; excitatory postsynaptic potential; heart development; ion transmembrane transport; locomotory behavior; nervous system development; nervous system process; neuromuscular synaptic transmission; protein heterooligomerization; regulation of acetylcholine secretion, neurotransmission; regulation of dendrite morphogenesis; regulation of membrane potential; regulation of muscle contraction; regulation of smooth muscle contraction; regulation of synaptic vesicle exocytosis; response to acetylcholine; response to drug; response to inorganic substance; response to nicotine; signal transduction; synaptic transmission involved in micturition; synaptic transmission, cholinergic
Reference #:  P04757 (UniProtKB)
Alt. Names/Synonyms: Acetylcholine receptor alpha 3 (neuronal nicotine); ACHA3; Acra3; cetylcholine receptor alpha 3 (neuronal nicotine); cholinergic receptor nicotinic alpha polypeptide 4; cholinergic receptor, nicotinic, alpha 3; cholinergic receptor, nicotinic, alpha polypeptide 3; Chrna3; nAChRA3; Neuronal acetylcholine receptor subunit alpha-3
Gene Symbols: Chrna3
Molecular weight: 56,998 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene