p63 Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. Belongs to the p53 family. Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues. 2 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 16 B1|16 17.37 cM
Cellular Component:  cytoplasm; cytosol; dendrite; Golgi apparatus; neuron projection; nuclear chromatin; nucleoplasm; nucleus; protein-containing complex; rough endoplasmic reticulum
Molecular Function:  chromatin binding; damaged DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; double-stranded DNA binding; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; p53 binding; protein binding; protein domain specific binding; sequence-specific DNA binding; transcription regulatory region DNA binding; WW domain binding
Biological Process:  anatomical structure formation involved in morphogenesis; animal organ morphogenesis; apoptotic process; cell aging; cell differentiation; cell proliferation; cellular response to DNA damage stimulus; chromatin remodeling; cloacal septation; cranial skeletal system development; developmental process; ectoderm and mesoderm interaction; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; epidermal cell differentiation; epidermal cell division; epidermis development; epithelial cell development; epithelial cell differentiation; establishment of planar polarity; establishment of skin barrier; female genitalia morphogenesis; hair follicle development; hair follicle morphogenesis; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; keratinocyte differentiation; keratinocyte proliferation; morphogenesis of a polarized epithelium; multicellular organism aging; multicellular organism development; negative regulation of apoptotic process; negative regulation of cellular senescence; negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of keratinocyte differentiation; negative regulation of mesoderm development; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; neuron apoptotic process; Notch signaling pathway; odontogenesis of dentin-containing tooth; pattern specification process; polarized epithelial cell differentiation; positive regulation of apoptotic signaling pathway; positive regulation of cell cycle G1/S phase transition; positive regulation of fibroblast apoptotic process; positive regulation of keratinocyte proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of Notch signaling pathway; positive regulation of osteoblast differentiation; positive regulation of somatic stem cell population maintenance; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; post-anal tail morphogenesis; prostate gland development; prostatic bud formation; protein homotetramerization; protein tetramerization; proximal/distal pattern formation; regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of epidermal cell division; regulation of transcription, DNA-templated; replicative cell aging; skeletal system development; skin epidermis development; skin morphogenesis; smooth muscle tissue development; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; sympathetic nervous system development; urinary bladder development
Reference #:  O88898 (UniProtKB)
Alt. Names/Synonyms: AI462811; delta; Ket; MGC115972; OTTMUSP00000023059; p51/p; P51/P63; P63; P73l; TAp; TP63; Tp73l; transformation related protein 63; Transformation-related protein 63; Trp5; Trp53rp1; Trp63; Tumor protein 63; Tumor protein p73-like
Gene Symbols: Tp63
Molecular weight: 76,789 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene