p63 Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. Belongs to the p53 family. Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues. 2 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 3q28
Cellular Component:  cytoplasm; cytosol; dendrite; Golgi apparatus; mitochondrion; nuclear chromatin; nucleoplasm; nucleus; protein-containing complex; rough endoplasmic reticulum
Molecular Function:  chromatin binding; damaged DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; p53 binding; protein binding; sequence-specific DNA binding; transcription regulatory region DNA binding; WW domain binding
Biological Process:  apoptotic process; cell proliferation; chromatin remodeling; cloacal septation; cranial skeletal system development; ectoderm and mesoderm interaction; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; epidermal cell division; epithelial cell development; establishment of planar polarity; establishment of skin barrier; female genitalia morphogenesis; hair follicle morphogenesis; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; keratinocyte differentiation; multicellular organism aging; negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of keratinocyte differentiation; negative regulation of mesoderm development; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; neuron apoptotic process; Notch signaling pathway; odontogenesis of dentin-containing tooth; polarized epithelial cell differentiation; positive regulation of fibroblast apoptotic process; positive regulation of keratinocyte proliferation; positive regulation of Notch signaling pathway; positive regulation of osteoblast differentiation; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of somatic stem cell population maintenance; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; post-anal tail morphogenesis; prostatic bud formation; protein homotetramerization; proximal/distal pattern formation; regulation of apoptotic process; regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of epidermal cell division; regulation of signal transduction by p53 class mediator; replicative cell aging; skeletal system development; skin morphogenesis; spermatogenesis; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; sympathetic nervous system development
Disease: Adult Syndrome; Ankyloblepharon-ectodermal Defects-cleft Lip/palate; Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/palate Syndrome 3; Limb-mammary Syndrome; Orofacial Cleft 8; Rapp-hodgkin Syndrome; Split-hand/foot Malformation 4
Reference #:  Q9H3D4 (UniProtKB)
Alt. Names/Synonyms: AIS; amplified in squamous cell carcinoma; B(p51A); B(p51B); Chronic ulcerative stomatitis protein; CUSP; EEC3; Keratinocyte transcription factor KET; KET; LMS; NBP; OFC8; p40; p51; p53CP; P63; P73H; P73L; RHS; SHFM4; TP53CP; TP53L; TP63; TP73L; Transformation-related protein 63; Tumor protein 63; tumor protein p53-competing protein; tumor protein p53-like; tumor protein p63; tumor protein p63 deltaN isoform delta; Tumor protein p73-like
Gene Symbols: TP63
Molecular weight: 76,785 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein