APLP2 May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts. Belongs to the APP family. Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell surface; DNA-binding; Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 9 A4|9 16.66 cM
Cellular Component:  integral component of membrane; membrane; nucleus; plasma membrane
Molecular Function:  DNA binding; heparin binding; identical protein binding; metal ion binding; protein binding; transition metal ion binding
Biological Process:  cellular copper ion homeostasis; cholesterol metabolic process; extracellular matrix organization; forebrain development; locomotory behavior; mating behavior; midbrain development; neuromuscular process controlling balance; regulation of epidermal growth factor-activated receptor activity; regulation of protein binding; suckling behavior
Reference #:  Q06335 (UniProtKB)
Alt. Names/Synonyms: AI790698; amyloid beta (A4) precursor-like protein 2; Amyloid-like protein 2; APLP-2; Aplp2; CDE1-binding protein CDEBP; CDEBP; CDEI box-binding protein
Gene Symbols: Aplp2
Molecular weight: 80,467 Da
Basal Isoelectric point: 4.63  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene