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SNX18
Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane. Belongs to the sorting nexin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Vesicle |
| Chromosomal Location of human Ortholog: 5q11.2 |
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Cellular Component:
clathrin-coated vesicle; cytoplasmic side of plasma membrane; cytoplasmic vesicle; extracellular exosome; plasma membrane; recycling endosome membrane
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Molecular Function:
phosphatidylinositol binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding
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Biological Process:
cleavage furrow formation; endocytosis; endosomal transport; mitotic cytokinesis; plasma membrane tubulation; positive regulation of autophagosome assembly; positive regulation of GTPase activity; protein transport; selective autophagy
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Reference #:
Q96RF0
(UniProtKB)
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Alt. Names/Synonyms: FLJ11997; FLJ32560; FLJ61062; MGC150827; MGC150829; SH3 and PX domain-containing protein 3B; SH3PX2; SH3PXD3B; SNAG1; SNX18; sorting nexin 18; sorting nexin associated golgi protein 1; Sorting nexin-18; Sorting nexin-associated Golgi protein 1
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Gene Symbols: SNX18
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Molecular weight:
68,894 Da
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Basal Isoelectric point:
5.44
Predict pI for various phosphorylation states
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