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NCK2
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Ubiquitous. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 2q12.2 |
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Cellular Component:
cytoplasm; cytosol; endoplasmic reticulum; postsynaptic density; vesicle membrane
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Molecular Function:
cytoskeletal adaptor activity; phosphotyrosine residue binding; protein binding; protein-containing complex binding; receptor signaling complex scaffold activity; scaffold protein binding; SH3/SH2 adaptor activity
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Biological Process:
actin filament organization; cell migration; dendritic spine development; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; immunological synapse formation; lamellipodium assembly; negative regulation of cell proliferation; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; negative regulation of peptidyl-serine phosphorylation; negative regulation of PERK-mediated unfolded protein response; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of actin filament polymerization; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of T cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of translation in response to endoplasmic reticulum stress; regulation of epidermal growth factor-activated receptor activity; signal complex assembly; signal transduction; T cell activation; vascular endothelial growth factor receptor signaling pathway
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Reference #:
O43639
(UniProtKB)
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Alt. Names/Synonyms: Cytoplasmic protein NCK2; GRB4; NCK adaptor protein 2; Nck-2; NCK2; NCKbeta; noncatalytic region of tyrosine kinase, beta; SH2/SH3 adaptor protein NCK-beta
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Gene Symbols: NCK2
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Molecular weight:
42,915 Da
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Basal Isoelectric point:
6.49
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Insulin Receptor Signaling
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T Cell Receptor Signaling
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Translation: eIF2
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Translation: eIF4E and p70S6K
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