|
NCK2
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Ubiquitous. Note: This description may include information from UniProtKB.
|
| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 2q12.2 |
|
Cellular Component:
cytoplasm; cytosol; endoplasmic reticulum; postsynaptic density; vesicle membrane
|
|
Molecular Function:
cytoskeletal adaptor activity; phosphotyrosine residue binding; protein binding; protein-containing complex binding; receptor signaling complex scaffold activity; scaffold protein binding; SH3/SH2 adaptor activity
|
|
Biological Process:
actin filament organization; cell migration; dendritic spine development; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; immunological synapse formation; lamellipodium assembly; negative regulation of cell proliferation; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; negative regulation of peptidyl-serine phosphorylation; negative regulation of PERK-mediated unfolded protein response; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of actin filament polymerization; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of T cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of translation in response to endoplasmic reticulum stress; regulation of epidermal growth factor-activated receptor activity; signal complex assembly; signal transduction; T cell activation; vascular endothelial growth factor receptor signaling pathway
|
|
Reference #:
O43639
(UniProtKB)
|
|
Alt. Names/Synonyms: Cytoplasmic protein NCK2; GRB4; Growth factor receptor-bound protein 4; NCK adaptor protein 2; Nck-2; NCK2; NCKbeta; noncatalytic region of tyrosine kinase, beta; SH2/SH3 adaptor protein NCK-beta
|
|
Gene Symbols: NCK2
|
|
Molecular weight:
42,915 Da
|
|
Basal Isoelectric point:
6.49
Predict pI for various phosphorylation states
|
|
CST Pathways:
Actin Dynamics
|
Insulin Receptor Signaling
|
T Cell Receptor Signaling
|
Translation: eIF2
|
Translation: eIF4E and p70S6K
|
