NCK2 Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 2q12.2
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum; postsynaptic density; vesicle membrane
Molecular Function:  cytoskeletal adaptor activity; phosphotyrosine residue binding; protein binding; protein-containing complex binding; receptor signaling complex scaffold activity; scaffold protein binding; SH3/SH2 adaptor activity
Biological Process:  actin filament organization; cell migration; dendritic spine development; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; immunological synapse formation; lamellipodium assembly; negative regulation of cell proliferation; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; negative regulation of peptidyl-serine phosphorylation; negative regulation of PERK-mediated unfolded protein response; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of actin filament polymerization; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of T cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of translation in response to endoplasmic reticulum stress; regulation of epidermal growth factor-activated receptor activity; signal complex assembly; signal transduction; T cell activation; vascular endothelial growth factor receptor signaling pathway
Reference #:  O43639 (UniProtKB)
Alt. Names/Synonyms: Cytoplasmic protein NCK2; GRB4; Growth factor receptor-bound protein 4; NCK adaptor protein 2; Nck-2; NCK2; NCKbeta; noncatalytic region of tyrosine kinase, beta; SH2/SH3 adaptor protein NCK-beta
Gene Symbols: NCK2
Molecular weight: 42,915 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Insulin Receptor Signaling  |  T Cell Receptor Signaling  |  Translation: eIF2  |  Translation: eIF4E and p70S6K
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein