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EFS
Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES. Belongs to the CAS family. The protein has been detected in lung and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 14q11.2 |
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Cellular Component:
cytoplasm; focal adhesion; plasma membrane
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Molecular Function:
protein binding; protein domain specific binding; SH3 domain binding
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Biological Process:
cell adhesion; cell migration; intracellular signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
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Reference #:
O43281
(UniProtKB)
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Alt. Names/Synonyms: Cas scaffolding protein family member 3; CAS3; CASS3; EFS; EFS1; EFS2; Embryonal Fyn-associated substrate; hEFS; signal transduction protein (SH3 containing); SIN
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Gene Symbols: EFS
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Molecular weight:
58,815 Da
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Basal Isoelectric point:
4.98
Predict pI for various phosphorylation states
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