EFS Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES. Belongs to the CAS family. The protein has been detected in lung and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: 
Molecular Function:  protein binding; protein domain specific binding; SH3 domain binding
Biological Process:  cell adhesion; intracellular signal transduction
Reference #:  O43281 (UniProtKB)
Alt. Names/Synonyms: Cas scaffolding protein family member 3; CAS3; CASS3; EFS; EFS1; EFS2; Embryonal Fyn-associated substrate; hEFS; signal transduction protein (SH3 containing); SIN
Gene Symbols: EFS
Molecular weight: 58,815 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein