ANK3 In skeletal muscle, required for costamere localization of DMD and betaDAG1. Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption. Isoform 5: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. Expressed in brain, neurons, muscles and other tissues. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 10q21.2
Cellular Component:  axon initial segment; basal plasma membrane; basolateral plasma membrane; bicellular tight junction; cell surface; costamere; cytosol; dendrite; endoplasmic reticulum; Golgi apparatus; intercalated disc; lateral plasma membrane; lysosome; neuromuscular junction; neuron projection; node of Ranvier; plasma membrane; postsynaptic membrane; sarcolemma; sarcoplasmic reticulum; spectrin-associated cytoskeleton; T-tubule; Z disc
Molecular Function:  cadherin binding; cytoskeletal anchor activity; cytoskeletal protein binding; protein binding; protein-macromolecule adaptor activity; spectrin binding; structural constituent of cytoskeleton; transmembrane transporter binding
Biological Process:  axonogenesis; cellular response to magnesium ion; cytoskeleton organization; establishment of protein localization; Golgi to plasma membrane protein transport; magnesium ion homeostasis; maintenance of protein location in plasma membrane; membrane assembly; mitotic cytokinesis; negative regulation of delayed rectifier potassium channel activity; neuromuscular junction development; neuronal action potential; plasma membrane organization; positive regulation of cation channel activity; positive regulation of cell communication by electrical coupling; positive regulation of gene expression; positive regulation of homotypic cell-cell adhesion; positive regulation of membrane depolarization during cardiac muscle cell action potential; positive regulation of membrane potential; positive regulation of protein targeting to membrane; positive regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; protein localization to axon; protein localization to plasma membrane; regulation of potassium ion transport; signal transduction
Disease: Mental Retardation, Autosomal Recessive 37
Reference #:  Q12955 (UniProtKB)
Alt. Names/Synonyms: ANK-3; ANK3; ankyrin 3; ankyrin 3, node of Ranvier (ankyrin G); ankyrin G119; Ankyrin-3; ankyrin-3, node of Ranvier; Ankyrin-G; FLJ45464; MRT37
Gene Symbols: ANK3
Molecular weight: 480,410 Da
Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene