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nAChRA3
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-3/CHRNA3 sub-subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of Human Ortholog: 15q25.1 |
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Cellular Component:
acetylcholine-gated channel complex; cell junction; dendrite; integral component of membrane; neuronal cell body; plasma membrane; plasma membrane raft; postsynaptic density; postsynaptic membrane
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Molecular Function:
acetylcholine binding; acetylcholine receptor activity; acetylcholine-gated cation-selective channel activity; ligand-gated ion channel activity; protein binding
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Biological Process:
acetylcholine receptor signaling pathway; activation of transmembrane receptor protein tyrosine kinase activity; behavioral response to nicotine; excitatory postsynaptic potential; ion transport; locomotory behavior; nervous system development; regulation of acetylcholine secretion, neurotransmission; regulation of dendrite morphogenesis; regulation of membrane potential; regulation of smooth muscle contraction; response to acetylcholine; signal transduction; synaptic transmission involved in micturition; synaptic transmission, cholinergic
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Disease: Bladder Dysfunction, Autonomic, With Impaired Pupillary Reflex And Secondary Cakut; Smoking As A Quantitative Trait Locus 3
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Reference #:
P32297
(UniProtKB)
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Alt. Names/Synonyms: ACHA3; BAIPRCK; cholinergic receptor nicotinic alpha 3 subunit; cholinergic receptor, nicotinic alpha 3; cholinergic receptor, nicotinic, alpha 3; cholinergic receptor, nicotinic, alpha 3 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 3; CHRNA3; LNCR2; MGC104879; NACHRA3; Neuronal acetylcholine receptor subunit alpha-3; neuronal nicotinic acetylcholine receptor, alpha3 subunit; PAOD2
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Gene Symbols: CHRNA3
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Molecular weight:
57,480 Da
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Basal Isoelectric point:
6.05
Predict pI for various phosphorylation states
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CST Pathways:
Alzheimer's Disease
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