nAChRA3 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-3/CHRNA3 sub-subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 15q25.1
Cellular Component:  acetylcholine-gated channel complex; cell junction; dendrite; integral component of membrane; neuronal cell body; plasma membrane; plasma membrane raft; postsynaptic density; postsynaptic membrane
Molecular Function:  acetylcholine binding; acetylcholine receptor activity; acetylcholine-gated cation-selective channel activity; ligand-gated ion channel activity; protein binding
Biological Process:  acetylcholine receptor signaling pathway; activation of transmembrane receptor protein tyrosine kinase activity; behavioral response to nicotine; excitatory postsynaptic potential; ion transport; locomotory behavior; nervous system development; regulation of acetylcholine secretion, neurotransmission; regulation of dendrite morphogenesis; regulation of membrane potential; regulation of smooth muscle contraction; response to acetylcholine; signal transduction; synaptic transmission involved in micturition; synaptic transmission, cholinergic
Disease: Bladder Dysfunction, Autonomic, With Impaired Pupillary Reflex And Secondary Cakut; Smoking As A Quantitative Trait Locus 3
Reference #:  P32297 (UniProtKB)
Alt. Names/Synonyms: ACHA3; BAIPRCK; cholinergic receptor nicotinic alpha 3 subunit; cholinergic receptor, nicotinic alpha 3; cholinergic receptor, nicotinic, alpha 3; cholinergic receptor, nicotinic, alpha 3 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 3; CHRNA3; LNCR2; MGC104879; NACHRA3; Neuronal acetylcholine receptor subunit alpha-3; neuronal nicotinic acetylcholine receptor, alpha3 subunit; PAOD2
Gene Symbols: CHRNA3
Molecular weight: 57,480 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein