TPH1 Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. Isoform 2 seems to be less widely expressed than isoform 1. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; EC; Oxidoreductase
Chromosomal Location of Human Ortholog: 7 B3|7 30.43 cM
Cellular Component:  cytoplasm; neuron projection
Molecular Function:  iron ion binding; metal ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; tryptophan 5-monooxygenase activity
Biological Process:  aromatic amino acid family metabolic process; bone remodeling; mammary gland alveolus development; negative regulation of ossification; positive regulation of fat cell differentiation; serotonin biosynthetic process
Reference #:  P17532 (UniProtKB)
Alt. Names/Synonyms: Tph; Tph1; Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; tryptophan hydroxylase 1
Gene Symbols: Tph1
Molecular weight: 51,343 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene