TPH1 Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. Isoform 2 seems to be less widely expressed than isoform 1. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; EC 1.14.16.4; Oxidoreductase
Chromosomal Location of Human Ortholog: 11p15.1
Cellular Component:  cytosol
Molecular Function:  iron ion binding
Biological Process:  aromatic amino acid family metabolic process; bone remodeling; circadian rhythm; indolalkylamine biosynthetic process; mammary gland alveolus development; negative regulation of ossification; oxidation-reduction process; positive regulation of fat cell differentiation; response to immobilization stress; serotonin biosynthetic process
Reference #:  P17752 (UniProtKB)
Alt. Names/Synonyms: indoleacetic acid-5-hydroxylase; L-tryptophan hydroxylase; MGC119994; TPH; TPH1; TPRH; TRPH; Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; tryptophan hydroxylase (tryptophan 5-monooxygenase); tryptophan hydroxylase 1
Gene Symbols: TPH1
Molecular weight: 50,985 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TPH1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene