SCN5A an integral membrane protein and a voltage-gated sodium channel subunit. Mediates the voltage-dependent sodium ion permeability of excitable membranes. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. Intracellular calcium levels regulate channel inactivation. Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2. Interacts with NEDD4, NEDD4L, WWP2 and GPD1L. Defects in this protein are a cause of long QT syndrome type 3 (LQT3). Belongs to the sodium channel (TC 1.A.1.10) family, Nav1.5/SCN5A subfamily. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 9 F3|9 71.33 cM
Cellular Component:  axon; caveola; cell surface; cytoplasm; endoplasmic reticulum; integral component of membrane; intercalated disc; lateral plasma membrane; membrane; plasma membrane; sarcolemma; sodium channel complex; T-tubule; voltage-gated sodium channel complex; Z disc
Molecular Function:  ankyrin binding; calmodulin binding; enzyme binding; fibroblast growth factor binding; ion channel activity; ion channel binding; nitric-oxide synthase binding; protein binding; protein domain specific binding; protein kinase binding; scaffold protein binding; sodium channel activity; ubiquitin protein ligase binding; voltage-gated ion channel activity; voltage-gated sodium channel activity; voltage-gated sodium channel activity involved in AV node cell action potential; voltage-gated sodium channel activity involved in bundle of His cell action potential; voltage-gated sodium channel activity involved in cardiac muscle cell action potential; voltage-gated sodium channel activity involved in Purkinje myocyte action potential; voltage-gated sodium channel activity involved in SA node cell action potential
Biological Process:  atrial cardiac muscle cell action potential; AV node cell action potential; AV node cell to bundle of His cell communication; bundle of His cell action potential; calcium ion homeostasis; cardiac muscle cell action potential involved in contraction; cardiac muscle contraction; cardiac ventricle development; cellular response to calcium ion; ion transport; membrane depolarization; membrane depolarization during action potential; membrane depolarization during atrial cardiac muscle cell action potential; membrane depolarization during AV node cell action potential; membrane depolarization during bundle of His cell action potential; membrane depolarization during cardiac muscle cell action potential; membrane depolarization during Purkinje myocyte cell action potential; membrane depolarization during SA node cell action potential; neuronal action potential; positive regulation of action potential; positive regulation of epithelial cell proliferation; positive regulation of heart rate; positive regulation of sodium ion transport; regulation of atrial cardiac muscle cell membrane depolarization; regulation of atrial cardiac muscle cell membrane repolarization; regulation of cardiac muscle cell contraction; regulation of heart rate; regulation of heart rate by cardiac conduction; regulation of ion transmembrane transport; regulation of sodium ion transmembrane transport; regulation of ventricular cardiac muscle cell membrane depolarization; regulation of ventricular cardiac muscle cell membrane repolarization; response to denervation involved in regulation of muscle adaptation; response to organic cyclic compound; SA node cell action potential; sodium ion transmembrane transport; sodium ion transport; transmembrane transport; ventricular cardiac muscle cell action potential
Reference #:  Q9JJV9 (UniProtKB)
Alt. Names/Synonyms: mH1; Nav1.5; Nav1.5c; Scn5a; SkM1; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type 5 subunit alpha; Sodium channel protein type V subunit alpha; sodium channel voltage-gated type V alpha polypeptide; sodium channel, voltage-gated, type V, alpha; sodium channel, voltage-gated, type V, alpha polypeptide; Voltage-gated sodium channel subunit alpha Nav1.5
Gene Symbols: Scn5a
Molecular weight: 227,576 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SCN5A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene