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SCN5A
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.5/SCN5A subfamily. Found in jejunal circular smooth muscle cells (at protein level). Expressed in human atrial and ventricular cardiac muscle but not in adult skeletal muscle, brain, myometrium, liver, or spleen. Isoform 4 is expressed in brain. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of mouse Ortholog: 9 F3|9 71.33 cM |
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Cellular Component:
anchoring junction; axon; caveola; cell surface; cytoplasm; endoplasmic reticulum; intercalated disc; lateral plasma membrane; membrane; nucleolus; nucleoplasm; plasma membrane; sarcolemma; sodium channel complex; T-tubule; voltage-gated sodium channel complex; Z disc
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Molecular Function:
ankyrin binding; calmodulin binding; enzyme binding; fibroblast growth factor binding; monoatomic cation channel activity; monoatomic ion channel activity; nitric-oxide synthase binding; protein binding; protein domain specific binding; protein kinase binding; scaffold protein binding; sodium channel activity; transmembrane transporter binding; ubiquitin protein ligase binding; voltage-gated monoatomic ion channel activity; voltage-gated sodium channel activity; voltage-gated sodium channel activity involved in AV node cell action potential; voltage-gated sodium channel activity involved in bundle of His cell action potential; voltage-gated sodium channel activity involved in cardiac muscle cell action potential; voltage-gated sodium channel activity involved in Purkinje myocyte action potential; voltage-gated sodium channel activity involved in SA node cell action potential
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Biological Process:
atrial cardiac muscle cell action potential; AV node cell action potential; AV node cell to bundle of His cell communication; bundle of His cell action potential; cardiac muscle cell action potential involved in contraction; cardiac muscle contraction; cardiac ventricle development; cellular response to calcium ion; membrane depolarization; membrane depolarization during action potential; membrane depolarization during atrial cardiac muscle cell action potential; membrane depolarization during AV node cell action potential; membrane depolarization during bundle of His cell action potential; membrane depolarization during cardiac muscle cell action potential; membrane depolarization during Purkinje myocyte cell action potential; membrane depolarization during SA node cell action potential; monoatomic ion transport; neuronal action potential; positive regulation of action potential; positive regulation of epithelial cell proliferation; positive regulation of heart rate; positive regulation of sodium ion transport; regulation of atrial cardiac muscle cell membrane depolarization; regulation of atrial cardiac muscle cell membrane repolarization; regulation of cardiac muscle cell contraction; regulation of heart rate; regulation of heart rate by cardiac conduction; regulation of monoatomic ion transmembrane transport; regulation of sodium ion transmembrane transport; regulation of ventricular cardiac muscle cell membrane depolarization; regulation of ventricular cardiac muscle cell membrane repolarization; response to denervation involved in regulation of muscle adaptation; response to organic cyclic compound; SA node cell action potential; sodium ion import across plasma membrane; sodium ion transmembrane transport; sodium ion transport; transmembrane transport; ventricular cardiac muscle cell action potential
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Reference #:
Q9JJV9
(UniProtKB)
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Alt. Names/Synonyms: mH1; Nav; Nav1; Nav1.5; Nav1.5c; Scn5a; SkM; SkM1; SkM2; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type 5 subunit alpha; Sodium channel protein type V subunit alpha; sodium channel voltage-gated type V alpha polypeptide; sodium channel, voltage-gated, type V, alpha; sodium channel, voltage-gated, type V, alpha polypeptide; voltage-gated sodium channel Nav1.5 variant a; voltage-gated sodium channel Nav1.5 variant b; Voltage-gated sodium channel subunit alpha Nav1.5
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Gene Symbols: Scn5a
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Molecular weight:
227,576 Da
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Basal Isoelectric point:
5.45
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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