GHF-1 Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5'-TAAAT-3'. Activates growth hormone and prolactin genes. Belongs to the POU transcription factor family. Class-1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 3p11.2
Cellular Component:  chromatin; cytosol; nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; lncRNA binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific double-stranded DNA binding
Biological Process:  adenohypophysis development; negative regulation of cell population proliferation; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II
Disease: Pituitary Hormone Deficiency, Combined, 1
Reference #:  P28069 (UniProtKB)
Alt. Names/Synonyms: CPHD1; GHF-1; GHF1; Growth hormone factor 1; PIT-1; PIT1; pituitary transcript factor 1; Pituitary-specific positive transcription factor 1; pituitary-specific transcription factor 1; POU class 1 homeobox 1; POU domain, class 1, transcription factor 1; POU1F1; POU1F1a
Gene Symbols: POU1F1
Molecular weight: 32,912 Da
Basal Isoelectric point: 8.36  Predict pI for various phosphorylation states
Select Structure to View Below

GHF-1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein